Results 141 to 150 of about 495,214 (384)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
CAPRI enables comparison of evolutionarily conserved RNA interacting regions
Nature Communications, 2019 Comprehensive characterisation of RNA-protein interactions requires different levels of resolution. Here, the authors present an integrated mass spectrometry-based approach that allows them to define the Drosophila RNA-protein interactome from the level ...
Amol Panhale +6 more
doaj +1 more source
Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus [PDF]
, 2021 Jie Wang +7 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
New Insights into Epigenetic Regulation of T Cell Differentiation [PDF]
, 2021 Avik Dutta +2 more
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Understanding epigenetics in health and human diseases – An overview
Journal of Integrative Medicine and ResearchEpigenetics, the study of heritable changes in gene expression without alterations to the DNA sequence, is crucial for the complex interplay of genetic and environmental factors influencing human health.
Avarna Agarwal, Prasanta Padhan
doaj +1 more source
Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders
Frontiers in Pharmacology, 2019 Excitatory amino acid transporter 2 (EAAT2) is the predominant astrocyte glutamate transporter involved in the reuptake of the majority of the synaptic glutamate in the mammalian central nervous system (CNS).
Mohammad Afaque Alam, Prasun K. Datta
doaj +1 more source
Cancer epigenetics: Moving forward
PLoS Genetics, 2018 Defects in chromatin modifiers and remodelers have been described both for hematological and solid malignancies, corroborating and strengthening the role of epigenetic aberrations in the etiology of cancer.
A. Nebbioso +3 more
semanticscholar +1 more source