Results 151 to 160 of about 495,214 (384)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
Nature Communications, 2017 Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers.
Fátima Valdés-Mora +18 more
doaj +1 more source
The Role of Epigenetics in Autoimmune/Inflammatory Disease
Frontiers in Immunology, 2019 Historically, systemic self-inflammatory conditions were classified as either autoinflammatory and caused by the innate immune system or autoimmune and driven by adaptive immune responses.
Anna E. A. Surace, C. Hedrich
semanticscholar +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The emerging role of epigenetics in human autoimmune disorders
Clinical Epigenetics, 2019 Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of ...
R. Mazzone +6 more
semanticscholar +1 more source
Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning [PDF]
, 2008 Heiner Niemann +3 more
openalex +1 more source
, 2023 Fangfang Wang +10 more
openalex +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Nature Communications, 2018 In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly ...
Claudia Isabelle Keller Valsecchi +5 more
doaj +1 more source