Results 151 to 160 of about 475,691 (380)
Epigenetics of hepatocellular carcinoma
Clinical and Translational Medicine, 2019 In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity.
T. Toh, J. Lim, E. Chow
semanticscholar +1 more source
Epigenetic engineering and the art of epigenetic manipulation [PDF]
Genome Biology, 2014 AbstractA report on the Epigenetic Engineering Meeting hosted by the Barts Institute of Cancer, held in London, UK, May 7 ...
openaire +4 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
Nature Communications, 2017 Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers.
Fátima Valdés-Mora +18 more
doaj +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Nature Communications, 2018 In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly ...
Claudia Isabelle Keller Valsecchi +5 more
doaj +1 more source
Cell size sets the diameter of the budding yeast contractile ring
Nature Communications, 2020 Budding yeast cell polarization is known to self-assemble, but it is still not clear what controls the size of the resulting septin ring. Here the authors show that the septin ring diameter is set by cell volume, ensuring that larger cells have larger ...
I. V. Kukhtevich +4 more
doaj +1 more source
Cancer epigenetics and epigenetical therapy
Journal of Experimental and Integrative Medicine, 2016 Gene expression mechanism are controlled and coordinated by epigenetic regulators, including histone modification, CpG-island methylation and chromatin looping. Imbalance of these epigenetic marks (epimutation) can lead to many anomalies including cancer. In recent years, research has suggested that cancer growth and survive through the combined effect
S. M. Asaduzzaman +6 more
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Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Triacylglycerol synthesis enhances macrophage inflammatory function
Nature Communications, 2020 As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear.
Angela Castoldi +14 more
doaj +1 more source