Results 191 to 200 of about 458,162 (417)
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Understanding how chromatin folding and enzyme competition affect rugged epigenetic landscapes [PDF]
arXivEpigenetics plays a key role in cellular differentiation and maintaining cell identity, enabling cells to regulate their genetic activity without altering the DNA sequence. Epigenetic regulation occurs within the context of hierarchically folded chromatin, yet the interplay between the dynamics of epigenetic modifications and chromatin architecture ...
arxiv
Phenotypic plasticity for life history traits in Drosophila melanogaster. II. Epigenetic mechanisms and the scaling of variances [PDF]
, 1993 M Gebhardt, Stephen C. Stearns
openalex +1 more source
Nature Communications, 2019 The position, shape and number of transcription start sites (TSS) regulate gene expression. Here authors present MAPCap, a method for high-resolution detection and differential expression analysis of TSS, and apply MAPCap to early fly development ...
Vivek Bhardwaj +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
On a Stochastic PDE Model for Epigenetic Dynamics [PDF]
arXivWe propose and analyze a stochastic model to investigate epigenetic mutations, i.e., modifications of the genetic information that control gene expression patterns in a cell but do not alter the DNA sequence. Epigenetic mutations are related to environmental fluctuations, which leads us to consider (additive) noise as the driving element for such ...
arxiv
Rate distortion coevolutionary dynamics and the flow nature of cognitive epigenetic systems [PDF]
arXiv, 2011 We outline a model for a cognitive epigenetic system based on elements of the Shannon theory of information and the statistical physics of the generalized Onsager relations. Particular attention is paid to the concept of the rate distortion function and from another direction as motivated by the thermodynamics of computing, the fundamental homology ...
arxiv
Pregnancy lipidomic profiles and DNA methylation in newborns from the CHAMACOS cohort. [PDF]
, 2019 Lipids play a role in many biological functions and the newly emerging field of lipidomics aims to characterize the varying classes of lipid molecules present in biological specimens.
Bradman, Asa +5 more
core
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Evolving Boolean Regulatory Networks with Epigenetic Control [PDF]
arXiv, 2013 The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by ...
arxiv