Results 261 to 270 of about 189,865 (294)

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

Epigenetic alterations in triple-negative breast cancer and their clinical implications for diagnosis and therapy. [PDF]

J Cancer
Go EJ, Oh JH.
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Biological Mechanisms Linking Social Adversity and Cognition. [PDF]

Public Health Rev
Liang A, Watt E, Gomaa N.
europepmc   +1 more source

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, EarlyView.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

Dissecting the pathogenic effects of ambient air pollution exposure and its blood DNA methylation markers on cardiovascular disease risk. [PDF]

Clin Epigenetics
Li W, Kong W, Shen C, Fan H, Shen Y, Zhang Y, Zheng L.   +6 more
europepmc   +1 more source

The emerging intertwined activities of metabolism and epigenetics unveils culprits and prospects in cancer. [PDF]

Exp Mol Med
Verma A, Lindroth AM.
europepmc   +1 more source

Breastfeeding in Italy. How "the first 1,000 days" discourse molecularises social expectations of intensive mothering. [PDF]

Front Sociol
Bandelli D.
europepmc   +1 more source

Progress in epigenetic research of breast cancer: a bibliometric analysis since the 2000s. [PDF]

Front Oncol
Yang H, Fang Y, Wang H, Lu T, Chen Q, Liu H.   +5 more
europepmc   +1 more source