Results 261 to 270 of about 495,214 (384)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Editorial: Immune-checkpoint inhibitors and immunometabolic reprogramming in cancer immunotherapy. [PDF]

Front Immunol
Kumar V, De Falco V.
europepmc   +1 more source

Targeting methyltransferase PRMT5 retards the carcinogenesis and metastasis of HNSCC via epigenetically inhibiting Twist1 transcription

, 2020
Zhaona Fan, Lihong He, Mianxiang Li, Ruoyan Cao, Miao Deng, Fan Ping, Xueyi Liang, Yuan He, Tong Wu, Xiaoan Tao, Jian Xu, Bin Cheng, Juan Xia   +12 more
openalex   +1 more source

Detection of somatic epigenetic variation in Norway spruce via targeted bisulfite sequencing [PDF]

, 2018
Katrin Heer, Kristian K Ullrich, Manuel Hiß, Sascha Liepelt, Ralf Schulze Brüning, Jiabin Zhou, Lars Opgenoorth, Stefan A. Rensing   +7 more
openalex   +1 more source

Epigenome Modifying Tools In Asthma [PDF]

, 2015
Adcock,, Brook, PO, Durham, AL, Perry, M
core   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Correction: IHC4 and COMBINE scores for enhanced prognostic stratification in HR+/HER2- breast cancer patients after neoadjuvant chemotherapy. [PDF]

Breast Cancer Res Treat
Huang Z, Liu Y, Li S, Li Y, Wu Z, He H, Yang Y, Jin L.   +7 more
europepmc   +1 more source

Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat [PDF]

, 2014
Xuefeng Xu, Qiongyao Hu, Lingfang Liang, Lei Wu, Weizhong Gu, Lili Tang, Linchen Fu, Lizhong Du   +7 more
openalex   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer

, 2019
Qiong Wang, Peipei Wang, Li Zhang, Mathewos Tessema, Lang Bai, Xiuling Xu, Qin Li, Xuelian Zheng, Bryanna Saxton, Wenshu Chen, Randy Willink, Zhiping Li, Lin Zhang, Steven A. Belinsky, Xia Wang, Bin Zhou, Yong Lin   +16 more
openalex   +1 more source