Results 321 to 330 of about 495,214 (384)

Molecular characterization of cell decay in inflammation and topological assignment of released cfDNA for integrative laboratory and radiological outcome assessment. [PDF]

Front Cell Infect Microbiol
Gerhards C, Nittka S, Ast V, Evliyaoglu O, Hedtke M, Hench J, Gerigk M, Krebs J, Teufel A, Froelich MF, Fischer A, Schoenberg SO, Neumaier M, Hertel A.   +13 more
europepmc   +1 more source

Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells

, 2017
Vladanka Topalović, Aleksandar Krstić, Marija Schwirtlich, Diletta Dolfini, Roberto Mantovani, Milena Stevanović, Marija Mojsin   +6 more
openalex   +2 more sources

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

TEAMwork: Interplay of Post-Transcriptional Mechanisms, Epigenetics and Metabolism in (Auto-)Immunity. [PDF]

Eur J Immunol
Rossi F, Turner M.
europepmc   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Epigenetic regulation of inflammation in post-operative organ dysfunction: A scoping review protocol. [PDF]

PLoS One
Wilson R, Fern C, Goodyear C, Shelley B.
europepmc   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Editorial: The impact of climate and environmental change on epigenetics and pediatric health. [PDF]

Front Pediatr
Zinkhan EK.
europepmc   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Pharmaco-Epigenetics and Epigenetic Drugs in Type 2 Diabetes: Can Epigenetics Predict Drug Efficiency? [PDF]

Biomedicines
Mkhize SS, Chuturgoon AA, Ghazi T, Machaba KE.   +3 more
europepmc   +1 more source