Advanced Science, EarlyView.Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi +5 more
wiley +1 more source
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Nutri-epigenetics of mitochondrial function and energy homeostasis in obesity. [PDF]
Genes NutrGoss LR, Voruganti VS.
europepmc +1 more source
A comprehensive narrative review on precision medicine approach to hypertension: exploring the role of genetics, epigenetics, microbiome, and artificial intelligence. [PDF]
J Health Popul NutrSami A +6 more
europepmc +1 more source
Diagnostic, Prognostic, and Predictive Molecular Biomarkers in Head and Neck Squamous Cell Carcinoma: A Comprehensive Review. [PDF]
J Clin MedMichcik A +9 more
europepmc +1 more source
Special Issue "Molecular Advances in Obstetrical and Gynaecological Disorders". [PDF]
Int J Mol SciChristopoulos P, Eleftheriades A.
europepmc +1 more source
Histone deacetylases in Duchenne muscular dystrophy: a role in the mechanism of disease and a target for inhibition. [PDF]
Clin EpigeneticsBertoldi M +9 more
europepmc +1 more source
Intermediate endophenotypes and epigenetic mechanisms of psychiatric disorders. [PDF]
Imaging Neurosci (Camb)Kremer TL +6 more
europepmc +1 more source