Results 181 to 190 of about 6,465 (257)

Evaluation, Diagnosis, and Treatment of Concomitant Movement Disorders in Genetic Epilepsies. [PDF]

Epilepsy Curr
Garris J, Abbott M, Axeen E, Tochen L, Schreiber JM.   +4 more
europepmc   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, Volume 11, Issue 4, Page 1329-1342, August 2026.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Epilepsy and coeliac disease in children: a narrative review. [PDF]

Front Pediatr
Lonoce L, Laschi E, Minerva M, Lotti F, Curcio MR, Francioni A, Pacenza M, Grosso S.   +7 more
europepmc   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Foundational Work in Absence Epilepsy: Laying the Groundwork and Establishing the Gold-Standard. [PDF]

Epilepsy Curr
Fine AL.
europepmc   +1 more source

Expanding the Genotypic Spectrum of POMGNT1‐Related Muscle‐Eye‐Brain Disease: A Case Report

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
Compound heterozygous variants in the POMGNT1 gene expand the genotypic spectrum of Muscle‐Eye‐Brain disease, highlighting severe epilepsy with status epilepticus. Despite long disease duration, seizure freedom was achieved with intensive antiseizure polytherapy, underscoring the importance of continued therapeutic optimization in dystroglycanopathies.
Evripidis Pityrigkas, Vasiliki Poulidou, Stefania Kalampokini, Eleni Liouta, Georgia Pepe, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source

Unraveling Lennox-Gastaut Syndrome: From Molecular Pathogenesis to Precision Diagnosis and Targeted Therapy Evolving Therapeutic Strategies. [PDF]

Int J Mol Sci
Na JH, Lee YM.
europepmc   +1 more source

Patient outcomes in KCNQ2 developmental and epileptic encephalopathy

Developmental Medicine &Child Neurology, Volume 68, Issue 8, Page 1063-1071, August 2026.
Abstract The aim of this study was to review and summarize the literature describing clinically observed or caregiver‐reported and patient‐reported KCNQ2 developmental and epileptic encephalopathy (DEE) outcomes. Three online databases and selected congress proceedings were searched (August 2023).
Grant Maclaine, Michele H. Potashman, Deepshikha Pawar, Sugandh Sharma, Katja Rudell, Jason Lerner, Vlad Coric, Anne T. Berg, John Millichap, Gil L'Italien   +9 more
wiley   +1 more source

Genetic-Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies. [PDF]

Epigenomes
Zaruha AG, Codreanu P, Coman MC, Novac Ii MA, Duță-Ion SG, Jugănaru IR, Hotinceanu IA, Dan A, Burtavel LM, Eftenoiu AE, Bârcă D, Ionescu A, Paraschiv C, Rădoi VE.   +13 more
europepmc   +1 more source

Decoding Brain Development and Function Through GABAergic Inhibitory Neurons

European Journal of Neuroscience, Volume 64, Issue 3, August 2026.
Interneuron subtype specification occurs case by case. Whereas some interneurons are specified very early, at the progenitor level, other interneurons develop final features during migration into the migratory stream or upon integration into specific cortical layers. The concept that interneuron specification can be significantly influenced by external
Renata Batista‐Brito, Christian Mayer, Mercedes Paredes, Carla G. Silva   +3 more
wiley   +1 more source