Results 81 to 90 of about 6,465 (257)

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Sustained seizure freedom with fenfluramine for refractory epilepsy due to 7q32‐q34 deletion syndrome

Epileptic Disorders, EarlyView.
Divya Veerapaneni, Abdulrahman Bukhari, Irfan S. Sheikh   +2 more
wiley   +1 more source

Are comorbid sleep disorders associated with higher risk for sudden unexpected death in epilepsy? Observations from a Canadian epilepsy clinic

Epilepsia, EarlyView.
Abstract Objective Pooled mortality is nearly three times higher in people with epilepsy (PWE). Approximately 80% of sudden unexpected death in epilepsy (SUDEP) events occur during sleep, and primary sleep disorders are prevalent in the general population and PWE.
Marion Lazaj, Ellen Lee, Tristan Derry, Helen Driver, Gavin P. Winston, Lysa Boissé Lomax, Ana Johnson, Garima Shukla   +7 more
wiley   +1 more source

Functional/dissociative seizures as a manifestation of forced normalization in eyelid myoclonia with absence epilepsy

Epileptic Disorders, EarlyView.
Fernando Vasquez‐Lopez, Jimena Gonzalez‐Salido, Salvador Martínez‐Medina, Irving Fuentes‐Calvo, Diego A. Barrios‐González, Betsy C. Vázquez‐Cruz, Juan Carlos Vera‐López, Jimena Colado‐Martinez, Orelli Ruiz‐Rodríguez, Pilar Robles‐Lomelin, Maximiliano Salgado Deza, Diego A. Hernandez, Álvaro José Moreno Avellán, Mario A. Sebastián Díaz, Daniel Crail‐Meléndez, Ángel Ruiz‐Chow, Iris E. Martínez‐Juárez   +16 more
wiley   +1 more source

Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...
Utku Uysal, Patrick Landazuri, David E. Burdette, Sanjay Patra, Angela N. Crudele, Dario J Englot, Jay R. Gavvala, Sandipan Pati, Lesley C. Kaye, Steven Ojemann, Daniel Barnett, Joseph Neimat, Adriana E. Palade, Shervin Rahimpour, Amir A. Arain, Robert Mark Richardson, Sydney S. Cash, Vicenta Salanova, Alexandra Urban, William P. Welch, Jamie Joseph Van Gompel, Keith Starnes, David Spencer, Lia D. Ernst, Ushtar Amin, Angelica Rivera‐Cruz, Patricia Dugan, Marytery Fajardo, Matt Lallas, Barbara C. Jobst, Nicole Odom, Jarod L. Roland, Jon T. Willie, Sameer A. Sheth, Alica M. Goldman, Christopher T. Skidmore, Chengyuan Wu, Cornelia Drees, Jonathon Parker, Taneeta Mindy Ganguly, Jerzy Szaflarski, Saadi Ghatan, Lise Johnson, Jacob Norman, Brett Wingeier, Cairn G. Seale, Martha J. Morrell, Nautilus Study Group   +47 more
wiley   +1 more source

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source

Insights into ANKRD11‐related epilepsy from 163 people

Epilepsia, EarlyView.
Abstract Objective Ankyrin repeat domain 11 gene (ANKRD11) is the key disease gene for autosomal dominant KBG syndrome, and a subset of affected individuals develop epilepsy. However, comprehensive characterization of epilepsy‐related phenotypes and genotype–phenotype correlations in ANKRD11 variant carriers remains limited.
Song Su, Jian Ma, Qi Zhang, Wandong Hu, Ying Ren, Wenchao Zhang, Hongwei Zhang   +6 more
wiley   +1 more source

Self-Limited Focal Epilepsies in Childhood: How Many and How to Treat

Pediatric Reports
Self-limited focal epilepsies in childhood (SELFEs), formerly referred to as “benign epilepsies in childhood”, constitute a heterogeneous group of epileptic conditions with onset predominantly in the neonatal, infantile, and childhood periods. A defining
Piero Pavone, Francesca Scrofani, Chiara Caruso, Enrico Parano, Agata Polizzi, Raffaele Falsaperla, Antonio Corsello, Giovanni Battista Dell’Isola, Xena Giada Pappalardo   +8 more
doaj   +1 more source

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video‐electroencephalographic study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to estimate the prevalence and characterize the semiology of co‐occurring functional/dissociative seizures (FDSs) and identify clinical features potentially associated with the development of video‐electroencephalography (video‐EEG)‐diagnosed FDSs in patients with idiopathic generalized epilepsy (IGE ...
Javier Peña‐Ceballos, Kishen Radhakrishna, Tenzin Choekyi, Clodagh O'Keeffe, Mohamed Ali, Alma O'Donnell, Tudor Munteanu, Patrick B. Moloney, Hany El Naggar, Gerard Mullins, Peter Widdess‐Walsh, Ronan D. Kilbride, Norman Delanty, Nuala McNicholas   +13 more
wiley   +1 more source

Raising resilience: A parenting intervention for families affected by childhood epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite behavioral concerns reported among children with epilepsy, evidence‐based family‐focused interventions designed for this population remain limited. The objectives of this study were to characterize behavioral concerns and parent mental health needs in families of children with epilepsy relative to children with non‐epileptic ...
Samantha J. Feldman, Bianca C. Bondi, Chantal C. Cheung, Heather Olivieri, Tricia S. Williams   +4 more
wiley   +1 more source