Results 31 to 40 of about 1,388,000 (303)

CACNA1A Mutations Associated With Epilepsies and Their Molecular Sub-Regional Implications

Frontiers in Molecular Neuroscience, 2022
PurposePreviously, mutations in the voltage-gated calcium channel subunit alpha1 A (CACNA1A) gene have been reported to be associated with paroxysmal disorders, typically as episodic ataxia type 2.
Xue-Lian Li, Xue-Lian Li, Zong-Jun Li, Xiao-Yu Liang, De-Tian Liu, Mi Jiang, Liang-Di Gao, Huan Li, Xue-Qing Tang, Yi-Wu Shi, Bing-Mei Li, Na He, Bin Li, Wen-Jun Bian, Yong-Hong Yi, Chuan-Fang Cheng, Chuan-Fang Cheng, Jie Wang   +17 more
doaj   +1 more source

PET Scanning in Partial Epilepsy [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1991
ABSTRACT:Many biologically active tracers are available for positron emission tomography (PET) investigations, but most studies of epilepsy have utilized l8F-fluorodeoxyglucose (FDG) to measure local cerebral metabolic rate for glucose. Over 70% of patients with medically refractory partial seizures demonstrate an interictal zone of hypometabolism ...
openaire   +2 more sources

Seizures in Offspring of Epileptic Parents

Pediatric Neurology Briefs, 1989
The risks Of unprovoked seizures in the offspring of parents with generalized versus partial epilepsies among 687 patients born in Rochester, MN between 1922 and 1985 and followed for the occurrence of seizures through 1986 are reported from the Division
J Gordon Millichap
doaj   +1 more source

A study on interictal depressive symptoms and laterality in temporal lobe and generalized epilepsies

Annals of Indian Psychiatry, 2017
Background: Mood disorders like inter-ictal depressive symptoms and inter-ictal major depressive episodes are the most frequent psychiatric co-morbidity seen in temporal lobe epilepsies with left hippocampal sclerosis than generalized epilepsies. Despite
Neena S Sawant, Biswarup M Ghosh
doaj   +1 more source

Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation [PDF]

Vojnosanitetski Pregled, 2010
Introduction. A sudden withdrawal of antiepileptic drugs gives higher rate of epileptic seizures in the settings of video electroencephalography (vEEG), monitoring that is a subject to further registration and analysis.
Ristić Aleksandar, Lavrnić Slobodan, Zović Ljubica, Vojvodić Nikola, Janković Slavko, Škrijelj Fadilj, Ercegovac Marko, Sokić Dragoslav   +7 more
doaj   +1 more source

Cessation of еpileptic seizures series using peroral valproate in an adult patient with partial epilepsy [PDF]

Vojnosanitetski Pregled, 2007
Introduction. Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of
Spasić Mirjana, Lukić Stevo
doaj   +1 more source

Current clinical evidence on topiramate pharmacokinetics [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Topiramate is biochemically classified as a fructopyranose sulphamate. Discovered as early as 1979, during middle 1980's it was approved in many countries for the treatment of epilepsies and migraine prevention.
Jakovljević Mihajlo, Jožef Maj, Vovk Tomaž, Janković Slobodan, Grabnar Iztok   +4 more
doaj   +1 more source

Interictal cerebral metabolism in partial epilepsies of neocortical origin [PDF]

, 1991
We performed interietal [18F]fluorodeoxyglucose positron emission tomography (FDG PET) in 24 patients with partial epilepsy of neocortical origin. Two-thirds of patients had regions of hypometabolism.
Risinger, M. W., Engel, Jr. , J., Mazziotta, J. C., Henry, Thomas R., Phelps, M. E., Sutherling, W. W., Levesque, M. F.   +6 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source