Results 241 to 250 of about 2,035,560 (322)

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Causal Relationship Between Epilepsy, Status Epilepticus and Sleep-Related Traits: A Bidirectional Mendelian Randomization Study. [PDF]

Brain Sci
Shin YW, Hong SB.
europepmc   +1 more source

Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits

Cell, 2011
O. Peñagarikano, B. Abrahams, Edward I. Herman, Kellen D. Winden, A. Gdalyahu, Hongmei Dong, L. Sonnenblick, R. Gruver, Joel Almajano, Anatol Bragin, P. Golshani, J. Trachtenberg, E. Peles, D. Geschwind   +13 more
semanticscholar   +1 more source

A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome

Autism Research, EarlyView.
ABSTRACT Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking.
Vic Lin, Samantha M. Matta, Julia E. Dallman, Suzanne Hosie, Manon Moreau, Ashley E. Franks, Thomas Bourgeron, Elisa L. Hill‐Yardin   +7 more
wiley   +1 more source

[Clinical response to brivaracetam in two cases of drug-resistant juvenile absence epilepsy]. [PDF]

An Sist Sanit Navar
Sanabria Sanchinel AA, Bol Marroquín BD.   +1 more
europepmc   +1 more source

Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population‐Based Birth Cohort Study

Autism Research, EarlyView.
ABSTRACT The long‐term outcomes of regression in autism spectrum disorder (ASD) remain unclear. Previous evidence suggests that autistic individuals with regression have poorer adulthood outcomes across various indices than those without regression. We compared two groups—those with and without regression in ASD—among 168 participants from a population‐
Satoru Minami, Mitsuaki Iwasa, Hiroko Ohzono, Daimei Sasayama, Hideo Honda   +4 more
wiley   +1 more source

Precision neuromodulation in epilepsy: from shared targets to personalized circuits. [PDF]

Brain Commun
Pati S.
europepmc   +1 more source

Paediatric rare diseases: Can large language models assist off‐label prescribing?

British Journal of Clinical Pharmacology, EarlyView.
Aims To evaluate the effectiveness and reliability of large language models (LLMs) in retrieving and synthesizing biomedical information to support off‐label drug prescribing in paediatric rare diseases, and to compare their performance with human‐authored references in terms of scientific rationale, adverse events and drug interactions.
Anna Flamigni, Giulia Zamagni, Gilda Paternuosto, Anna Arbo   +3 more
wiley   +1 more source

All Influencing Factors Should Be Taken into Account When Calculating Outcome Predictors for Paediatric Status Epilepticus [Letter]. [PDF]

Neuropsychiatr Dis Treat
Finsterer J.
europepmc   +1 more source

Pregabalin dependence, withdrawal, suicidality and psychosis reports: A disproportionality analysis of the Australian adverse events database

British Journal of Clinical Pharmacology, EarlyView.
Aims Globally, Australia has the highest per capita consumption rate of pregabalin, commonly prescribed for neuropathic pain. Emerging evidence suggests pregabalin may be associated with the onset or recurrence of several potentially life‐threatening psychiatric events in some individuals.
Amy G. McNeilage, Ali Gholamrezaei, Bridin Murnion, Suzanne Nielsen, Claire E. Ashton‐James   +4 more
wiley   +1 more source