Results 101 to 110 of about 69,244 (314)

Genetic Variation in Calcium Channel Gene in Idiopathic Generalized Epilepsies

Pediatric Neurology Briefs, 2008
Researchers at Women's And Children's Hospital, North Adelaide, and other centers in Australia and Canada screened 240 individuals from 167 families with idiopathic generalized epilepsy and generalized epilepsy with febrile seizures plus (GEFS + ) and 95
J Gordon Millichap
doaj   +1 more source

Genetic Causes of Generalized Epilepsies [PDF]

Seminars in Neurology, 2015
Generalized epilepsies, particularly the idiopathic or genetic generalized epilepsies (GGEs), represent some of the most common epilepsies. Clinical genetic data including family studies and twin studies provide compelling evidence for a prominent genetic impact.
openaire   +2 more sources

Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14

, 2009
Childhood absence epilepsy (CAE) is an idiopathic generalised epilepsy (IGE) characterised by typical absence seizures manifested by transitory loss of awareness with 2.5–4 Hz spike-wave complexes on ictal EEG.
Sander, Thomas, Eeg-Olofsson, O, Everett, KV, Everett, Kate V., Friis, Mogens Laue, Dulac, Olivier, Siren, Auli, Dooley, Joseph M, Aschauer, H, Kjeldsen, MJ, Dulac, O, Wirrell, Elaine, Covanis, Athanasios, Brouwer, Oebele, Covanis, A, Sirén, A, Aicardi, Jean, Gardiner, RM, Durner, Martina, Robinson, R, Nabbout, Rima, Gardiner, R. Mark, McKeigue, Paul, Sander, T, Dooley, JM, Gardiner, R Mark, McKeigue, Paul; id_orcid, Chioza, BA, Aschauer, Harald, Everett, Kate V, Eeg-Olofsson, Orvar, Brouwer, O, Nabbout, R, McKeigue, P, Robinson, Robert, Chioza, Barry A., Dooley, Joseph M., Nashef, L, Feucht, Martha, Feucht, M, Guerrini, R, Aicardi, J, Durner, M, Nashef, Lina, Wirrell, E, Callenbach, P, Guerrini, Renzo, Callenbach, Petra, Chioza, Barry A, Friis, ML, Kjeldsen, Marianne Juel, Eeg-Olofsson, Orvar,   +51 more
core   +1 more source

Late-Onset Generalized Myoclonic Seizure: Case Report

, 2021
Most of the epileptic seizures that begin at an advanced age are focal onset seizures due to an underlying structural lesion. Generalized myoclonic seizures, usually seen in adolescence, are very rare in elderly patients without a history of epilepsy. In
Baburhan GÜLDİKEN, Hülya ÖZKAN, Merve Melodi ÇAKAR, Aslı SERT SUNAL, Sunal, Asli Sert, Sezgin KEHAYA, Kehaya, Sezgin, Guldiken, Baburhan, Ozkan, Hulya, Cakar, Merve Melodi   +9 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Electrophysiologic Study of Cognitive Functions in Epileptic Patients

مجلة كلية الطب, 2011
Background: Cognitive dysfunctions in epileptic patients may develop due to the neurophysiologic changes related to seizures or antiepileptic drugs. Objectives: The aim of this longitudinal study was to evaluate the cognitive dysfunction in epileptic ...
Shaymaa J. Mohammed, Zaid Al-Madfai, Mazin M. H. Al-Owath   +2 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Bayesian multi-modal model comparison: a case study on the generators of the spike and the wave in generalized spike–wave complexes [PDF]

, 2010
We present a novel approach to assess the networks involved in the generation of spontaneous pathological brain activity based on multi-modal imaging data.
Lemieux, L., Vaudano, A.E., Daunizeau, Jean, Lemieux, L, Daunizeau, J., Vaudano, A E, Daunizeau, J, Lemieux, Louis, VAUDANO, Anna Elisabetta   +8 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Ictal MEG-EEG Study to Localize the Onset of Generalized Seizures: To See Beyond What Meets the Eye

Brain Sciences
Introduction: Patients with generalized epilepsy are rarely referred for advanced diagnostics like magnetoencephalography (MEG). This is due to the assumption that generalized seizures cannot be localized noninvasively.
Valentina Gumenyuk, Oleg Korzyukov, Noam Peled, Patrick Landazuri, Olga Taraschenko, Sheridan M. Parker, Darya Frank, Spriha Pavuluri   +7 more
doaj   +1 more source