Results 151 to 160 of about 403,746 (315)

Implementation of Deep Neural Networks to Classify EEG Signals using Gramian Angular Summation Field for Epilepsy Diagnosis [PDF]

arXiv, 2020
This paper evaluates the approach of imaging timeseries data such as EEG in the diagnosis of epilepsy through Deep Neural Network (DNN). EEG signal is transformed into an RGB image using Gramian Angular Summation Field (GASF). Many such EEG epochs are transformed into GASF images for the normal and focal EEG signals.
arxiv  

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

The molecular genetics of RASopathies: An update on novel disease genes and new disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022
Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia, Yoko Aoki, Bruce D. Gelb   +2 more
wiley   +1 more source

Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I

Clinical and Developmental Immunology, 2006
Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma ...
Yukitoshi Takahashi, Kazumi Matsuda, Yuko Kubota, Jiro Shimomura, Etsuko Yamasaki, Tatsuya Kudo, Katsuyuki Fukushima, Hitoshi Osaka, Noriyuki Akasaka, Atsushi Imamura, Shinji Yamada, Naomi Kondo, Tateki Fujiwara   +12 more
doaj   +1 more source

Efficiency of vagus nerve stimulation in epilepsy (literature review and case report)

Русский журнал детской неврологии, 2019
Despite significant advances in epileptology, approximately one-third of patients suffer from drug-resistant epilepsy. Numerous approaches are currently available to treat epilepsy; however, there are still many patients with treatment-resistant epilepsy,
O. A. Pylaeva, V. A. Chadaev, M. Yu. Bobylova, K. Yu. Mukhin   +3 more
doaj   +1 more source

Towards Early Diagnosis of Epilepsy from EEG Data [PDF]

arXiv, 2020
Epilepsy is one of the most common neurological disorders, affecting about 1% of the population at all ages. Detecting the development of epilepsy, i.e., epileptogenesis (EPG), before any seizures occur could allow for early interventions and potentially more effective treatments.
arxiv  

An estimate of the prevalence of epilepsy in Sub-Saharan Africa:A systematic analysis [PDF]

, 2012
Epilepsy is a leading serious neurological condition worldwide and has particularly significant physical, economic and social consequences in Sub–Saharan Africa.
Adeloye, Davies, Chan, Kit Yee, George-Carey, Rhiannon, Grant, Elizabeth, Kolčić, Ivana, Paul, Abigail   +5 more
core   +2 more sources

The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies

Advanced Science, EarlyView.
This work explores the process of morning awakening of the human brain using polysomnography paired with simultaneous stereo‐electroencephalography, a method that provides high spatial and temporal resolution for examining brain activity. Awakening is characterized by an increase in high‐frequency spectral power and connectivity.
Tamir Avigdor, Guoping Ren, Chifaou Abdallah, François Dubeau, Christophe Grova, Birgit Frauscher   +5 more
wiley   +1 more source

Clinical overview on RASopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley   +1 more source

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Advanced Science, EarlyView.
NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu, Liang Xu, Yu Xie, Abhijeet Sambangi, Shreya Swaminathan, Zifei Pei, Wenyu Ji, Zeru Li, Yaowei Guo, Zhifei Li, Gong Chen   +10 more
wiley   +1 more source