Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]
, 2020 OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A +3 more
core +2 more sources
Demonstration project on epilepsy in Brazil - WHO/ILAE/IBE Global Campaign Against Epilepsy - A foreword [PDF]
, 2007 In 2002, ASPE (Assistência à Saúde de Pacientes com Epilepsia)* initiated an Epilepsy Demonstration Project (DP) in Brazil as part of the Global Campaign Against Epilepsy "Epilepsy out of the Shadows", led by the World Health Organization (WHO), the ...
de Boer, HM +4 more
core +2 more sources
Italian Wikipedia and epilepsy: an infodemiological study of online information-seeking behavior [PDF]
, 2018 Wikipedia is the most commonly accessed source of health information by both healthcare professionals and the lay public worldwide. We aimed to evaluate information-seeking behavior of Internet users searching the Italian Wikipedia for articles related ...
Bragazzi, Nicola Luigi +8 more
core +1 more source
Structural imaging biomarkers of sudden unexpected death in epilepsy. [PDF]
, 2015 Sudden unexpected death in epilepsy is a major cause of premature death in people with epilepsy. We aimed to assess whether structural changes potentially attributable to sudden death pathogenesis were present on magnetic resonance imaging in people who ...
Balestrini, Simona +12 more
core +3 more sources
Ictal kissing: occurrence and etiology. [PDF]
, 2016 Ictal kissing is a rare semiological manifestation in patients with epilepsy. We tried to estimate its occurrence and characterize the underlying etiology.
Asadi-Pooya, Ali Akbar +1 more
core +2 more sources
Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency) [PDF]
, 2010 Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of L-{alpha}-aminoadipic semialdehyde/L-{Delta}
Adam +50 more
core +11 more sources
Effect of neurostimulation on cognition and mood in refractory epilepsy. [PDF]
, 2018 Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to ...
Chan, Alvin Y +3 more
core +1 more source
Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect [PDF]
, 2015 Patients with epilepsy have a high prevalence of comorbid mood disorders. This study aims to evaluate whether negative affect in epilepsy is associated with dysfunction of emotion regulation.
Boon, Paul +6 more
core +4 more sources
Word Adjacency Graph Modeling: Separating Signal From Noise in Big Data [PDF]
, 2016 There is a need to develop methods to analyze Big Data to inform patient-centered interventions for better health outcomes. The purpose of this study was to develop and test a method to explore Big Data to describe salient health concerns of people with ...
Groves, Doyle +4 more
core +1 more source
Naming fMRI predicts the effect of temporal lobe resection on language decline
Annals of Clinical and Translational Neurology, 2019 Objective To develop language functional MRI (fMRI) methods that accurately predict postsurgical naming decline in temporal lobe epilepsy (TLE). Methods Forty‐six patients with TLE (25 left) and 19 controls underwent two overt fMRI paradigms (auditory ...
Karin Trimmel +10 more
doaj +1 more source