Results 11 to 20 of about 267,218 (255)

Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons

Frontiers in Molecular Neuroscience, 2020
Gene therapy approaches using viral vectors for the overexpression of target genes have been for several years the focus of gene therapy research against neurological disorders.
Valentina Di Maria, Marine Moindrot, Martin Ryde, Antonino Bono, Luis Quintino, Marco Ledri   +5 more
doaj   +1 more source

Naming fMRI predicts the effect of temporal lobe resection on language decline

Annals of Clinical and Translational Neurology, 2019
Objective To develop language functional MRI (fMRI) methods that accurately predict postsurgical naming decline in temporal lobe epilepsy (TLE). Methods Forty‐six patients with TLE (25 left) and 19 controls underwent two overt fMRI paradigms (auditory ...
Karin Trimmel, Louis A. vanGraan, Gloria G. Gonzálvez, Anja Haag, Lorenzo Caciagli, Sjoerd B. Vos, Silvia Bonelli, Meneka Sidhu, Pamela J. Thompson, Matthias J. Koepp, John S. Duncan   +10 more
doaj   +1 more source

Limitations of a Short Demographic Questionnaire for Bedside Estimation of Patients’ Global Cognitive Functioning in Epilepsy Patients

Frontiers in Neurology, 2018
ObjectivesThe German socio-demographic estimation scale was developed by Jahn et al. (1) to quickly predict premorbid global cognitive functioning in patients. So far, it has been validated in healthy adults and has shown a good correlation with the full
Iris Gorny, Kristina Krause, Anita Albert, Sabrina Schneider, Leona Möller, Lena Habermehl, Adam Strzelczyk, Adam Strzelczyk, Felix Rosenow, Felix Rosenow, Anke Hermsen, Anke Hermsen, Susanne Knake, Katja Menzler   +13 more
doaj   +1 more source

Genetic generalized epilepsies with frontal lesions mimicking migratory disorders on the epilepsy monitoring unit

Epilepsia Open, 2020
Objective Some patients with genetic generalized epilepsy (GGE) may present with ambiguous and atypical findings and even focal brain abnormalities. Correct diagnosis may therefore be difficult.
Susanne Fauser, Thomas Cloppenborg, Tilman Polster, Ulrich Specht, Friedrich G. Woermann, Christian G. Bien   +5 more
doaj   +1 more source

Surgical treatment of pediatric intractable frontal lobe epilepsy due to malformation of cortical development

Acta Epileptologica, 2022
Background Malformation of cortical development (MCD) is a common cause of intractable epilepsy in children. In this study, the effectiveness of frontal lobe epilepsy (FLE) surgery in children with intractable epilepsy due to MCD was assessed and its ...
Hao Yu, Qiang Lv, Qingzhu Liu, Shuang Wang, Taoyun Ji, Ruofan Wang, Wen Wang, Dongming Wang, Yuwu Jiang, Xiaoyan Liu, Lixin Cai   +10 more
doaj   +1 more source

RLAE

Эпилепсия и пароксизмальные состояния, 2020
Decision of the All-Russian Society of Neurologists Presidium 23.12.2019;Russian League Against Epilepsy.
Russian League Against Epilepsy
doaj  

Impairment of emotional expression detection after unilateral medial temporal structure resection

Scientific Reports, 2021
Detecting emotional facial expressions is an initial and indispensable component of face-to-face communication. Neuropsychological studies on the neural substrates of this process have shown that bilateral amygdala lesions impaired the detection of ...
Wataru Sato, Naotaka Usui, Reiko Sawada, Akihiko Kondo, Motomi Toichi, Yushi Inoue   +5 more
doaj   +1 more source

Removal of a temporal lobe cavernous angioma to control epileptic seizures in a patient with tuberous sclerosis complex

Heliyon, 2020
Purpose: A patient with tuberous sclerosis complex (TSC) and a left temporal cavernous angioma (CA) presented with treatment-resistant epilepsy. We evaluated the patient to determine the best treatment option.
Kazuki Sakakura, Ayataka Fujimoto, Naoki Ichikawa, Shimpei Baba, Hideo Enoki, Tohru Okanishi   +5 more
doaj   +1 more source

A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy

Epilepsia Open, 2023
Objective Post‐traumatic epilepsy (PTE) is an acquired epilepsy that develops in the months or years following a traumatic brain injury (TBI) and can lead to substantial personal, financial, and societal burden.
Sloka S. Iyengar, Laura S. Lubbers, Lauren Harte‐Hargrove, CURE Epilepsy Post‐Traumatic Initiative Advisors, and Investigators   +3 more
doaj   +1 more source

Optogenetic inhibition of chemically induced hypersynchronized bursting in mice

Neurobiology of Disease, 2014
Synchronized activity is common during various physiological operations but can culminate in seizures and consequently in epilepsy in pathological hyperexcitable conditions in the brain.
Fredrik Berglind, Marco Ledri, Andreas Toft Sørensen, Litsa Nikitidou, Miriam Melis, Pascal Bielefeld, Deniz Kirik, Karl Deisseroth, My Andersson, Merab Kokaia   +9 more
doaj   +1 more source