Results 81 to 90 of about 1,687,814 (309)

Advanced treatment of intractable childgood epilepsy. [PDF]

open access: yes, 2008
Twenty to thirty percent of children with epilepsy continue to have seizures despite anti-epileptic drugs (AEDs) treatment and are defined as medically intractable epilepsy.
최금옥   +3 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

open access: yesAdvanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters   +12 more
wiley   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

open access: yesAdvanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li   +8 more
wiley   +1 more source

Long-Term Seizure and Antiepileptic Drug Outcomes After Epilepsy Surgery in Adults

open access: yes, 2015
Epilepsy surgery is an effi cacious treatment for selected persons with drug-resistant focal epilepsy, rendering many seizure-free and others signifi cantly improved.
Edelvik, Anna,   +5 more
core   +1 more source

Intelligence quotient (IQ) as a predictor of epilepsy surgery outcome

open access: yes, 2022
© 2022 Elsevier Inc. All rights reserved.Introduction: About one-third of patients with epilepsy have a refractory form which is associated with important economic and psychosocial burden. Most of these patients also suffer from comorbidities. One of the
Susana Loureiro   +11 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

open access: yesAdvanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan   +16 more
wiley   +1 more source

Addressing the epilepsy surgery gap: Impact of community/tertiary epilepsy center collaboration

open access: yesEpilepsy & Behavior Reports, 2020
To assess whether a formal collaboration between a non-surgical, community epilepsy center and a surgical, tertiary-care epilepsy center can improve patient progress throughout the pre-surgical referral process, and to elucidate predictors of referral ...
Keyan Peterson   +5 more
doaj   +1 more source

Changes in quality of life and self-perspective related to surgery in patients with temporal lobe epilepsy

open access: yes, 2004
Purpose. To evaluate changes in intractable epilepsy patients in terms of quality of life, depression, anxiety, stigma, and impact of epilepsy before and after ...
Canbeyli, R   +4 more
core   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

open access: yesAdvanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan   +13 more
wiley   +1 more source

Chorea–athetosis-like hyperkinetic seizures in temporal lobe epilepsy: insights from stereo-EEG in three patients

open access: yesEpilepsy & Behavior Reports
Purpose: To characterize the clinical and electrographic features of temporal lobe epilepsy (TLE) presenting with chorea–athetosis-like hyperkinetic seizures and to delineate the underlying seizure network using stereo-electroencephalography (SEEG ...
Jun Zhuang   +7 more
doaj   +1 more source

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