Results 91 to 100 of about 144,099 (307)

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

A case report: retigabine induced oral mucosal dyspigmentation of the hard palate [PDF]

, 2015
Background Dyspigmentation of the oral mucosa has a multitude of aetiological causes. Retigabine, a new antiepileptic drug, has the potential side effect of inducing a blue/purple pigmentation of the oral mucosa in addition to the skin, lips, nails and ...
Beacher, Nicholas G., Brodie, Martin J., Goodall, Christine   +2 more
core   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Memory Rehabilitation Strategies in Nonsurgical Temporal Lobe Epilepsy: A Review [PDF]

, 2017
open8siPeople with temporal lobe epilepsy (TLE) who have not undergone epilepsy surgery often complain of memory deficits. Cognitive re- habilitation is employed as a remedial intervention in clinical settings, but research is limited and findings ...
Alderighi, Marzia, Bosco, Anna, Del Felice, Alessandra, Grisafi, Davide, Martinato, Matteo, Masiero, Stefano, Sander, Josemir W., Thompson, Pamela J.   +7 more
core   +2 more sources

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

The white matter connectome as an individualized biomarker of language impairment in temporal lobe epilepsy. [PDF]

, 2019
ObjectiveThe distributed white matter network underlying language leads to difficulties in extracting clinically meaningful summaries of neural alterations leading to language impairment.
Bahrami, Naeim, Balachandra, Akshara R, Bonilha, Leonardo, Drane, Daniel L, Kaestner, Erik, Lalani, Sanam J, Macari, Anna Christina, McDonald, Carrie R, Paul, Brianna M, Reyes, Anny, Voets, Natalie L   +10 more
core   +2 more sources

The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models

Advanced Science, EarlyView.
Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková, Jan Švec, Marie Jakešová, Jiří Ehlich, Imrich Gablech, Eric Daniel Głowacki   +5 more
wiley   +1 more source

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol [PDF]

, 2015
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy.
A Bathen-Noethen, A Ciantis De, A Pakozdy, AA Raymond, AJ Hall, AK Shah, Akos Pakozdy, AM McIntosh, Andrea Fischer, Andrea Tipold, AR Deibler, CJ Abramson, Clare Rusbridge, DK Thompson, E Wagner, Edward E. Patterson, EJ Ives, EL So, F Cendes, F Rosenow, GS Berns, GS Berns, H Goldberg, Heidrun Potschka, Holger A. Volk, I Craven, J Laothamatas, J Oertzen Von, J Velmurugan, J Wellmer, J Wellmer, Jacques Penderis, Jelena Jovanovik, JS Duncan, JW Wheless, K Ono, Karen Muñana, Kaspar Matiasek, KL Stadler, KM Casey, KM Fiest, L Gygax, L Heske, L Kearsley-Fleet, LM Mellema, LS Garosi, Luisa De Risio, M Guye, M Konar, M Schwartz, Marjorie Milne, ME Milne, Mette Berendt, Michael Podell, MJ Fernandes, MS Anaya Garcia, N Farid, N Ogata, NK Focke, O Jacqmot, P Singh, P Szmuk, PF Cook, PM Smith, PT Wei, R Goncalves, R Kuzniecky, R Neppl, R Vasta, R Viitmaa, R Viitmaa, RA Thames, RL Wolf, Robyn G. Farqhuar, S Hecht, S Mizoguchi, S Torisu, Sam Long, SD Shorvon, Simon Platt, Sofie F. M. Bhatti, SP Knowler, T Guadalupe, T Hammen, T Kuwabara, TJ Oertzen von, TS Jokinen, U Ebert, V Jantti, V Martle, Veronika M. Stein, WD Gaillard, YM Lim, YS Ding, Z Haneef   +94 more
core   +6 more sources

Surgery for epilepsy

Seizure, 2001
While medical treatment remains the first line of treatment for epilepsy, surgery provides effective long-term control in suitable patients. Detailed investigations are necessary to prove suitability and in order to choose the appropriate procedure. This article gives an outline of the investigative programme and the various operative approaches. Novel
openaire   +3 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source