Results 71 to 80 of about 18,265 (273)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The vital cofactors NADH and NADPH are prone to hydration, forming hydroxylated redox‐inactive derivatives (NADHX and NADPHX) in cells. These damaged metabolites are repaired by two highly conserved enzymes, an NAD(P)HX dehydratase (NAXD) and an NAD(P)HX epimerase (NAXE).
Myrto Patraskaki, Najmesadat Seyedkatouli, Lisa Schlicker, Marc O. Warmoes, Maria Lorena Cordero‐Maldonado, Ursula Heins‐Marroquin, Carole L. Linster   +6 more
wiley   +1 more source

(1S)-1,2-O-Benzylidene-α-d-glucurono-6,3-lactone

Acta Crystallographica Section E, 2009
X-ray crystallographic analysis has established that the major product from the protection of d-glucoronolactone with benzaldehyde is (1S)-1,2-O-benzylidene-α-d-glucurono-6,3-lactone, C13H12O6, rather than the R epimer.
David J. Watkin, George W. J. Fleet, Robert A. Clarkson, Alexander C. Weymouth-Wilson, Daniel Best, Sarah F. Jenkinson   +5 more
doaj   +1 more source

Investigation of the biosynthesis of exopolysaccharides within the biofilm matrix of Pseudomonas aeruginosa and Pseudomonas syringae pv. actinidiea : a thesis presented in partial fulfilment of the requirements for degree of Doctor of Philosophy in Microbiology and Genetics at Massey University, Manawatu, New Zealand [PDF]

, 2017
Polysaccharides are highly abundant natural biopolymers, which have biologically significant structural functions in living organisms. Various polysaccharides, with specific physicochemical properties, contribute to biofilm formation; defined as cell ...
Ghods, Shirin
core  

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

Drug Testing and Analysis, Volume 18, Issue 2, Page 245-259, February 2026.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Mario Thevis, Andreas Thomas, Michael Petrou, Emmanuel N. Pitsinos   +5 more
wiley   +1 more source

Inhibitors of sterol synthesis. Tritium-labeled 26-hydroxycholesterol of high specific activity from a byproduct of the Clemmensen reduction of diosgenin.

Journal of Lipid Research, 1994
(25R)-26-Hydroxycholesterol (I) was synthesized in six steps from (22Z,25R)-cholesta-5,22-diene-3 beta,26-diol (II) in 31% overall yield. The 26-tert-butyldiphenylsilyl ether of II was converted via its 3 beta-tosylate to (22Z,25R)-6 beta-methoxy-26 ...
Y Ni, A Kisic, W K Wilson, G J Schroepfer, Jr   +3 more
doaj   +1 more source

Recent progress in the synthesis of six-membered aminocyclitols (2008-2017) [PDF]

, 2018
Aminocyclitols are of interest as glucosidase inhibitors, as probes for the study of pseudoglycosyltransferases, and as potential therapeutics for the treatment of Gaucher’s disease.
Donaldson, William
core   +1 more source

The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage [PDF]

, 2001
Enediyne antitumor antibiotics have attracted immense attention among chemists and biologists alike because of their unique chemical structures, potent antitumor activities, and fascinating biological modes of action.
Absolute, Ando T., Chromophore, Effects, Enantiomerically 0., For, Iida K., Isolation, Kobayashi S., Maki T., Mita T., Myers A. G., Neocarzinostatin, Role, Sato I., Sato I., Takahashi K., Total   +17 more
core   +1 more source

Environmental Influence on the Untargeted Foliar Metabolome of Naturally Growing Mitragyna Species in Thailand

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom). Using untargeted gas chromatography–mass spectrometry (GC–MS), 409 secondary volatile metabolites were annotated across the four species.
Tushar Andriyas, Nisa Leksungnoen, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Rossarin Tansawat, Pakawat Sirilertpanich   +5 more
wiley   +1 more source

Controlled diastereoselectivity at the alkene-geometry through selective encapsulation: E-Z photoisomerization of oxazolidinone-functionalized enecarbamates within hydrophobic nano-cavities [PDF]

, 2007
Photoisomerization of encapsulated Z-enecarbamates within the hydrophobic chiral cavities of γ-CD showed higher diastereoselectivities in the photoproducts than those obtained in solution.
Adam, Waldemar, Dyer, Joanne, Inoue, Yoshihisa, Jockusch, Steffen, Saito, Hideaki, Sivaguru, J., Turro, Nicholas J.   +6 more
core   +2 more sources