Results 71 to 80 of about 8,953 (240)

S‐Adenosyl‐d‐Methionine as a Non‐Physiological Substrate for a Wide Range of SAM‐Dependent Enzymes

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Philipp Germer, Lukas Gericke, Lars‐Hendrik Koeppl, Ziruo Zou, Emely Jockmann, Marco Kuge, Katrin Zoller, Hannah Herrmann, Ronja Fuderer, Michael K. F. Mohr, Agnes Bartels, Göksu Oral, Peer Lukat, Gunhild Layer, Michael Müller, Wulf Blankenfeldt, Lena Barra, Jennifer N. Andexer   +17 more
wiley   +1 more source

Genomics-inspired discovery of massiliachelin, an agrochelin epimer from Massilia sp. NR 4-1

Beilstein Journal of Organic Chemistry, 2019
A putative siderophore locus was detected in the genome of the violacein-producing bacterium Massilia sp. NR 4-1 and predicted to direct the biosynthesis of a molecule that is structurally related to the thiazoline-containing siderophore micacocidin.
Jan Diettrich, Hirokazu Kage, Markus Nett   +2 more
doaj   +1 more source

β-d-Gulose

Acta Crystallographica Section E, 2014
The title compound, C6H12O6, a C-3 position epimer of d-galactose, crystallized from an aqueous solution, was confirmed as β-d-pyranose with a 4C1 (C1) conformation.
Tomohiko Ishii, Shunsuke Ohga, Kazuhiro Fukada, Kenji Morimoto, Genta Sakane   +4 more
doaj   +1 more source

Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method [PDF]

, 2020
Noriko Fujii, Takumi Takata, Ingu Kim, Toshiya Matsubara   +3 more
openalex   +1 more source

Sphingolipid bases. A revisitation of the O-methyl derivatives of sphingosine. Isolation and characterization of diacetate derivatives, with revised 13C nuclear magnetic resonance assignments for D-erythro-sphingosine.

Journal of Lipid Research, 1995
As described by Carter et al. (J. Biol. Chem. 1951. 192: 197-207), O-methyl derivatives of sphingosine are formed upon acid hydrolysis of sphingolipids in the presence of methanol.
A Kisic, M Tsuda, R J Kulmacz, W K Wilson, G J Schroepfer, Jr   +4 more
doaj   +1 more source

Alkaloids from Hippeastrum papilio

Molecules, 2011
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus ...
Jaume Bastida, Jean Paulo de Andrade, José Angelo S. Zuanazzi, Carles Codina, Francesc Viladomat, Strahil Berkov   +5 more
doaj   +1 more source

Total Synthesis of Sacrolide A and Cytotoxic Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria, Kamel Hadj‐Kaddour, Alexis Giraudon, Jawad Belkheir, Alexandre Guy, Thierry Durand, Magali Gary‐Bobo, Camille Oger   +7 more
wiley   +1 more source

3-Epiabruslactone A, a New Triterpene Lactone Isolated from Austroplenckia populnea

Journal of the Brazilian Chemical Society, 1998
A new lactonic triterpene isolated from the heartwood of Austroplenckia populnea (Celastraceae) was characterized as 3alpha-hydroxyolean-12-en-29,22alpha-olide (the gamma-lactone of the 3alpha,22alpha-dihydroxyolean-12-en-29alpha-oic acid), the 3-epimer ...
Silva Grácia Divina de Fátima, Duarte Lucienir Pains, Paes Helena Clara da Silva, Sousa José Rêgo de, Nonato Maria Cristina, Portezani Paulo José, Mascarenhas Yvonne Primerano   +6 more
doaj  

8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

Beilstein Journal of Organic Chemistry, 2007
There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds.
Thomas A. Munro, Katharine K. Duncan, Richard J. Staples, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon Jr., Bruce M. Cohen   +7 more
doaj   +1 more source

Whole-body spatially-resolved metabolomics method for profiling the metabolic differences of epimer drug candidates using ambient mass spectrometry imaging [PDF]

, 2019
Zhigang Luo, Dan Liu, Xuechao Pang, Wanqi Yang, Jiuming He, Ruiping Zhang, Chenggen Zhu, Yanhua Chen, Xin Li, Jianjun Zhang, Jian‐Gong Shi, Zeper Abliz   +11 more
openalex   +1 more source