Results 1 to 10 of about 21,587 (210)

Single chiral center epimerization-modulated multi-carrier-free oral hydrogel for remolding inflammatory microenvironment via PI3K/Akt/NF-κB and MAPK signaling pathways [PDF]

Bioactive Materials
The self-assembly of biomolecules with chiral centers in nature has garnered significant attention due to its biomedical potential. However, how single chiral center epimerization influences molecular co-assembly remains unclear.
Wenmin Pi, Gen Li, Hailing Qiu, Yihang Zhao, Yaozhi Zhang, Xinru Tan, Jihui Lu, Zhijia Wang, Xuemei Huang, Penglong Wang   +9 more
doaj   +2 more sources

Cross-Kingdom Enzymatic Strategies for Deoxynivalenol Detoxification: Computational Analysis of Structural Mechanisms and Evolutionary Adaptations [PDF]

Microorganisms
Deoxynivalenol (DON) is a trichothecene mycotoxin produced by Fusarium species that frequently contaminates cereal crops, representing a major threat to food safety, public health, and agricultural productivity.
Francisco J. Enguita, Ana Lúcia Leitão
doaj   +2 more sources

Epimerization of Deoxynivalenol by the Devosia Strain A6-243 Assisted by Pyrroloquinoline Quinone

Toxins, 2021
Deoxynivalenol (DON) is a secondary metabolite produced by several Fusarium species that is hazardous to humans and animals after entering food chains.
Hui Gao, Jiafeng Niu, Hua Yang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Fengxia Lu, Meirong Chen   +7 more
doaj   +1 more source

(2R,4S,5S)-5-Methoxy-4-methyl-3-oxohept-6-en-2-yl benzoate

IUCrData, 2021
The title compound, C16H20O4, was synthesized in the course of the total synthesis of fusaequisin A in order to verify and confirm the configurations of the stereogenic centers and to exclude the possibility of epimerization during the methylation ...
Ann-Christin Schmidt, Lyuba Iovkova, Martin Hiersemann   +2 more
doaj   +1 more source

Poly(L-lactide) Epimerization and Chain Scission in the Presence of Organic Bases

Macromol, 2022
Organocatalysis for polymer chemistry has become a subject of significant interest in the last two decades. In this contribution, we have studied the evolution of the microstructure of poly(L-lactide) in solution in toluene at 105 °C in the presence of ...
Julie Meimoun, Audrey Favrelle-Huret, Julien De Winter, Philippe Zinck   +3 more
doaj   +1 more source

Synthesis of Four Orthogonally Protected Rare l-Hexose Thioglycosides from d-Mannose by C-5 and C-4 Epimerization

Molecules, 2022
l-Hexoses are important components of biologically relevant compounds and precursors of some therapeuticals. However, they typically cannot be obtained from natural sources and due to the complexity of their synthesis, their commercially available ...
Fruzsina Demeter, Ilona Bereczki, Anikó Borbás, Mihály Herczeg   +3 more
doaj   +1 more source

Two-Step Epimerization of Deoxynivalenol by Quinone-Dependent Dehydrogenase and Candida parapsilosis ACCC 20221

Toxins, 2023
Deoxynivalenol (DON), one of the main mycotoxins with enteric toxicity, genetic toxicity, and immunotoxicity, and is widely found in corn, barley, wheat, and rye.
Yuqian Tang, Dingna Xiao, Chendi Liu
doaj   +1 more source

Unambiguous Stereochemical Assignment of Cyclo(Phe-Pro), Cyclo(Leu-Pro), and Cyclo(Val-Pro) by Electronic Circular Dichroic Spectroscopy

Molecules, 2021
2,5-diketopiperazines (DKPs) are cyclic dipeptides ubiquitously found in nature. In particular, cyclo(Phe-Pro), cyclo(Leu-Pro), and cyclo(Val-Pro) are frequently detected in many microbial cultures.
Alison Domzalski, Liliana Margent, Valeria Vigo, Faizunnahar Dewan, Naga Vara Kishore Pilarsetty, Yujia Xu, Akira Kawamura   +6 more
doaj   +1 more source

IR action spectroscopy of glycosaminoglycan oligosaccharides [PDF]

, 2020
Glycosaminoglycans (GAGs) are a physio- and pharmacologically highly relevant class of complex saccharides, possessing a linear sequence and strongly acidic character.
Freyse, Joanna, Grabarics, Márkó, Helden, Gert von, Lettow, Maike, Meijer, Gerard, Mucha, Eike, Pagel, Kevin, Polewski, Łukasz, Rademann, Jörg, Thomas, Daniel A.   +9 more
core   +2 more sources

Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium

Microorganisms, 2021
Clostridioides difficile is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against C. difficile is important for elucidating the mechanisms by which C.
Amber D. Reed, Casey M. Theriot
doaj   +1 more source