Acta Crystallographica Section E: Crystallographic Communications, 2016 The isomeric title compounds, C12H13NO4 (Ia) and C12H13NO4 (IIa), the products of an usual thermal C6-epimerization of 5-oxo-1,2,3,5,5a,6,7,9b-octahydro-7,9a-epoxypyrrolo[2,1-a]isoindole-6-carboxylic acid, represent the two different diastereomers and ...
Dmitry S. Poplevin +4 more
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Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide [PDF]
, 2011 The potential therapeutic benefit of compounds able to activate AMPA receptors (AMPArs) has led to a search for new AMPAr positive modulators. Among them, 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide (1 ...
Battisti, UMBERTO MARIA +8 more
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Beilstein Journal of Organic Chemistry, 2012 The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach.
James R. Cochrane +3 more
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Metabolism of Cholesterol and Bile Acids by the Gut Microbiota
Pathogens, 2013 The human gastro-intestinal tract hosts a complex and diverse microbial community, whose collective genetic coding capacity vastly exceeds that of the human genome. As a consequence, the gut microbiota produces metabolites from a large range of molecules
Philippe Gérard
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Genetic and functional characterization of the gene cluster directing the biosynthesis of putisolvin I and II in Pseudomonas putida strain PCL1445 [PDF]
, 2008 Pseudomonas putida PCL1445 secretes two cyclic lipopeptides, putisolvin I and putisolvin II, which possess a surface-tension-reducing ability, and are able to inhibit biofilm formation and to break down biofilms of Pseudomonas species including ...
Bloemberg, G.V. +3 more
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Frontiers in Plant Science, 2017 Catechin epimerization is an important factor affecting tea catechin compositions and thereby tea quality. However, a lack of tea germplasms with high non-epicatechins limits relative research.
Changsong Chen +8 more
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Catalyst Site Epimerization during the Kinetic Resolution of Chiral α-Olefins by Polymerization [PDF]
, 2008 A new enantiopure C1-symmetric olefin polymerization precatalyst, (1,2-SiMe_2)_2{η^5-C_5H_2-4-((S)-CHEtCMe_3)}{η^5-C_5H-3,5-(CHMe_2)_2}ZrCl_2, (S)-2, was synthesized, and its use for the kinetic resolution of 3-methyl-substituted racemic α-olefins was ...
Bercaw, John E. +2 more
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Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
Nature Communications, 2023 The lasso peptide MS-271 is a ribosomally synthesized and post-translationally modified peptide (RiPP) consisting of 21 amino acids with D-tryptophan at the C-terminus, and is derived from the precursor peptide MslA.
Yu Nakashima +6 more
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Homochirality in an early peptide world
, 2006 A recently proposed model of non-autocatalytic reactions in dipeptide reactions leading to spontaneous symmetry breaking and homochirality is examined. The model is governed by activation, polymerization, epimerization and depolymerization of amino acids.
Axel Brandenburg +3 more
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Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence [PDF]
, 2018 A modular and diastereodivergent synthesis of tetrahydro-1H-pyrrolo[1,2d]diazepine-(2,5)-diones is presented. The tetrahydropyrrolodiazepinedione scaffold is obtained via a base-mediated three-step isomerization/tandem cyclization of amino acid-coupled ...
Brown, Lauren E. +3 more
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