Results 141 to 150 of about 58,973 (229)

Reducing Epistasis and Pleiotropy Can Avoid the Survival of the Flattest Tragedy

Biology
This study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the “survival of the flattest” (SoF) fitness landscape.
Priyanka Mehra, Arend Hintze
doaj   +1 more source

Distributed transformer for high order epistasis detection in large-scale datasets

Scientific Reports
Understanding the genetic basis of complex diseases is one of the most important challenges in current precision medicine. To this end, Genome-Wide Association Studies aim to correlate Single Nucleotide Polymorphisms (SNPs) to the presence or absence of ...
Miguel Graça, Ricardo Nobre, Leonel Sousa, Aleksandar Ilic   +3 more
doaj   +1 more source

Functional bottlenecks can emerge from non-epistatic underlying traits [PDF]

arXiv
Protein fitness landscapes frequently exhibit epistasis, where the effect of a mutation depends on the genetic context in which it occurs, \textit{i.e.}, the rest of the protein sequence. Epistasis increases landscape complexity, often resulting in multiple fitness peaks.
arxiv  

THE EFFECT OF EPISTASIS AND GAMETIC UNBALANCE ON GENETIC LOAD [PDF]

Genetics, 1966
S. K. Jain, R. W. Allard, P. E. Hansche
openaire   +3 more sources

Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster. [PDF]

G3 (Bethesda)
da Silva Ribeiro T, Lollar MJ, Sprengelmeyer QD, Huang Y, Benson DM, Orr MS, Johnson ZC, Corbett-Detig RB, Pool JE.   +8 more
europepmc   +1 more source

Improving genomic selection in hexaploid wheat with sub-genome additive and epistatic models. [PDF]

G3 (Bethesda)
Tessele A, González-Diéguez DO, Crossa J, Johnson BE, Morris GP, Fritz AK.   +5 more
europepmc   +1 more source

Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis. [PDF]

Nat Commun
Chitra U, Arnold B, Raphael BJ.
europepmc   +1 more source

A method for finding epistatic effects of maternal and fetal variants. [PDF]

Front Genet
Nodzenski M, Shi M, Umbach DM, Kidd B, Petty T, Weinberg CR.   +5 more
europepmc   +1 more source

Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis. [PDF]

Mol Biol Evol
Hebert JD, Tang YJ, Szamecz M, Andrejka L, Lopez SS, Petrov DA, Boross G, Winslow MM.   +7 more
europepmc   +1 more source

Deep learning captures the effect of epistasis in multifactorial diseases. [PDF]

Front Med (Lausanne)
Perelygin V, Kamelin A, Syzrantsev N, Shaheen L, Kim A, Plotnikov N, Ilinskaya A, Ilinsky V, Rakitko A, Poptsova M.   +9 more
europepmc   +1 more source