Results 141 to 150 of about 37,358 (239)

On Epistasis

, 2012
In this note, we compare two previously introduced notions  of epistasis and prove that they are essentially ...
Verschoren, A., Hove, H. van
core  

FvGI–FvCO–FvFT1 pathway activates FvTFL1 in long days to repress flowering in woodland strawberry (Fragaria vesca)

New Phytologist, Volume 252, Issue 3, Page 1269-1282, November 2026.
Natural variation of flowering time correlates with FvFT1 and FvTFL1 expression in European Fragaria vesca accessions. Summary Photoperiod is a stable seasonal signal. Although photoperiodic flowering is well understood in short‐day (SD) and long‐day (LD) annual plants, the regulatory mechanisms in perennials remain elusive.
Quan Zhou, Sergei Lembinen, Tuomas Toivainen, Takeshi Kurokura, Guangxun Fan, Paula Elomaa, Elli Koskela, Timo Hytönen   +7 more
wiley   +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk

Annals of Neurology, Volume 100, Issue 4, Page 737-750, October 2026.
Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier‐Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean‐François Deleuze, Orio Dols‐Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean‐Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius   +24 more
wiley   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Another explanation for apparent epistasis

, 2014
Epistasis occurs when the effect of a genetic variant on a trait is dependent on genotypes of other variants elsewhere in the genome. Hemani et al. recently reported the detection and replication of many instances of epistasis between pairs of variants ...
AB Singleton (21284156), MA Tuke (21834629), DG Hernandez (16171487), TM Frayling (7644461), MA Nalls (7713782), S Bandinelli (7644431), D Melzer (14728009), AR Wood (7715282), L Ferrucci (682240), MN Weedon (7655270)   +9 more
core   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, Volume 159, Issue 7, Page 1715-1734, 1 October 2026.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Application of Omics Technologies for Cowpea Improvement

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Cowpea (Vigna unguiculata) is a vital crop for food security, nutrition, and climate resilience in sub‐Saharan African and other semi‐arid regions. However, its improvement is constrained by the complexity of polygenic traits such as drought tolerance, pest resistance, and seed quality.
Junior S. Kamara, Festus O. Olasupo, Abdoul‐Razak Oumarou Mahamane, Katleho S. Selele   +3 more
wiley   +1 more source

Epistasis and unitation

, 2012
Normalized epistasis measures links between separate bits in binary strings, used to represent data to be optimized with respect to a given fitness function.
Verschoren, A., Suys, D., Iglesias, M. T., Vidal, C.   +3 more
core  

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF‐3α‐BNIP3 Axis

Aging Cell, Volume 25, Issue 10, October 2026.
Aging heart shows mitophagy flux congestion and mitochondrial dysfunction. Aberrant activation of the HIF‐3α‐BNIP3 axis induces mitophagy flux congestion in the aging heart. Mitochondrial transplantation rectifies the HIF‐3α‐BNIP3 axis and restores mitophagy flux by elevating ATP production in the aging heart.
Ning Jin, Li Zhou, Haixia Gui, Jingjing Tang, Xiaozhen Huang, Wenting Wang, Guorong Jin, Haiqin Cheng, Yuxiang Liang, Xinyi Geng, Zhiwei Peng, Hong Zhao, Zhizhen Liu, Jun Xie   +13 more
wiley   +1 more source

The Evolution of Fitness Landscapes: From Visualizing Evolution to Controlling It. [PDF]

Cancers (Basel)
Parks ME, Chen P, Wu J, Scott JG.
europepmc   +1 more source