Results 131 to 140 of about 68,669 (249)
Repeatability of evolution on epistatic landscapes
, 2015 Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes.
Bauer, Benedikt, Gokhale, Chaitanya S.
core +1 more source
Identifying Epistasis in Cancer Genomes: A Delicate Affair.
Cell, 2019 Recent studies of the tumor genome seek to identify cancer pathways as groups of genes in which mutations are epistatic with one another or, specifically, "mutually exclusive." Here, we show that most mutations are mutually exclusive not due to pathway ...
J. van de Haar +5 more
semanticscholar +1 more source
Genome‐wide associations of leaf spectral variation in MAGIC lines of Nicotiana attenuata
Ecology, Volume 107, Issue 4, April 2026.Abstract The application of in‐field and aerial spectroscopy to assess functional and phylogenetic variation in plants has led to novel ecological insights and supports global assessments of plant biodiversity. Understanding how plant genetic variation influences reflectance spectra will help harness this potential for biodiversity monitoring and ...
Cheng Li +7 more
wiley +1 more source
Can We Breed Microbiomes to Sustain Plant Productivity?
Microbial Biotechnology, Volume 19, Issue 4, April 2026.Plant domestication unintentionally reshaped crop microbiomes. We propose extending breeding beyond plant genomes to include the microbiome, integrating rewilding, QTL‐guided recruitment and ecological network design. Treating the microbiome as a selectable trait may unlock durable crop resilience under climate stress. ABSTRACT Global food systems face
Noémie De Zutter, Kris Audenaert
wiley +1 more source
Quantitative BiologyEpistasis is a ubiquitous phenomenon in genetics, and is considered to be one of main factors in current efforts to unveil missing heritability of complex diseases.
Yahan Li +4 more
doaj +1 more source
Life, 2018 The domino theory of gene loss states that when some particular gene loses its function and cripples a cellular function, selection will relax in all functionally related genes, which may allow for the non-functionalization and loss of these genes.
David J. Martínez-Cano +3 more
doaj +1 more source
Learning the pattern of epistasis linking genotype and phenotype in a protein
Nature Communications, 2017 Understanding the pattern of epistasis—the non-independence of mutations—is critical for relating genotype and phenotype. However, the combinatorial complexity of potential epistatic interactions has severely limited the analysis of this problem.
F. J. Poelwijk +2 more
semanticscholar +1 more source
A century of theories of balancing selection
Biological Reviews, Volume 101, Issue 2, Page 804-825, April 2026.ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka +10 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Incomplete understanding of the mechanisms of epistasis between two or more substitutions in a protein can hamper protein-engineering strategies. With Escherichia coli transketolase as a model, we explore the epistatic interactions between a
Haoran Yu, P. Dalby
semanticscholar +1 more source
Molecular Ecology, Volume 35, Issue 8, April 2026.ABSTRACT Post‐glacial recolonisation of Fennoscandia created secondary contact zones in many species, offering opportunities to study how gene flow and selection contribute to their establishment and maintenance. Here, we analyse genomic data from three boreal tree species—Picea abies, Betula pendula and Pinus sylvestris—sampled along a latitudinal ...
Pilar Herrera‐Egoavil +5 more
wiley +1 more source