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Haplotype applications in genomic selection. [PDF]
Genome BiolMacNish TR, Bergmann T, Edwards D.
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On the limits of detection of epistatic higher-order interactions
Camacho-Mateu J +4 more
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Epistasis and the changing fitness landscapes of SARS-CoV-2
Sesta L, Neher RA.
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Proceedings of the Royal Society B: Biological Sciences, 2011 Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions—called epistasis—have been the topic of a vast research effort. Systems and developmental biologists study epistasis to understand the genotype–phenotype map, whereas evolutionary biologists recognize the fundamental importance of epistasis for ...
Timothy Cooper +2 more
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Dynamics in Epistasis Analysis
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2018Finding regulatory relationships between genes, including the direction and nature of influence between them, is a fundamental challenge in the field of molecular genetics. One classical approach to this problem is epistasis analysis. Broadly speaking, epistasis analysis infers the regulatory relationships between a pair of genes in a genetic pathway ...
Aseel Awdeh +3 more
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Symbolic Modeling of Epistasis
Human Heredity, 2007The workhorse of modern genetic analysis is the parametric linear model. The advantages of the linear modeling framework are many and include a mathematical understanding of the model fitting process and ease of interpretation. However, an important limitation is that linear models make assumptions about the nature of the data being modeled.
Jason H, Moore +5 more
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Epistasis in Neuropsychiatric Disorders
Trends in Genetics, 2017The contribution of epistasis to human disease remains unclear. However, several studies have now identified epistatic interactions between common variants that increase the risk of a neuropsychiatric disorder, while there is growing evidence that genetic interactions contribute to the pathogenicity of rare, multigenic copy-number variants (CNVs) that ...
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