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Chronic infections can generate SARS-CoV-2-like bursts of viral evolution without epistasis. [PDF]
Virus EvolRodríguez-Horta E +3 more
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A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium. [PDF]
GeneticsJohri P, Charlesworth B.
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, 2005 [Resumen] En esta memoria se profundiza en el análisis del concepto de epistasis, Se muestra como -conjuntamente con el orden de una función - la epistasis permite explicar el comportamiento de algunas funciones cuyos extremos son conocidos (y su dificultad tambien) y que habitualmente sirven como "funciones de laboratorio" en el estudio de la ...
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Efficiency of Recurrent Genomic Selection in Panmictic Populations. [PDF]
Animals (Basel)Viana JMS, Silva JPAD, Lopes PS.
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Beyond the Mutation Abyss: Revisiting SARS-CoV-2 Receptor-Binding Domain Evolution from ACE2 Binding Optimization to Immune Epitope Remodeling. [PDF]
PathogensSoliman OA +3 more
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A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads. [PDF]
GeneticsJohri P, Charlesworth B.
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Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid-resistant β-lactamase mutants. [PDF]
Protein SciRadojković M +6 more
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A methodology for calculating the rarity of diverse proteins based on functional specificity and thermodynamic stability. [PDF]
PLoS OneMiller BJ.
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Using machine learning to predict and analyze complex trait diseases: Lessons from a simple abstract model. [PDF]
PLoS OneMaimon E, Bondi O, Moult J, Unger R.
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