Results 211 to 220 of about 68,669 (249)
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Epistasis and intramolecular networks in protein evolution.
Current Opinion in Structural Biology, 2021Proteins are molecular machines composed of complex, highly connected amino acid networks. Their functional optimization requires the reorganization of these intramolecular networks by evolution.
C. Miton, Karol Buda, N. Tokuriki
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Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Nature CatalysisEpistasis, the non-additive effect of mutations, can provide combinatorial improvements to enzyme activity that substantially exceed the gains from individual mutations. Yet the molecular mechanisms of epistasis remain elusive, undermining our ability to
Christopher Fröhlich +7 more
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The Causes and Consequences of Genetic Interactions (Epistasis).
Annual review of genomics and human genetics (Print), 2019The same mutation can have different effects in different individuals. One important reason for this is that the outcome of a mutation can depend on the genetic context in which it occurs. This dependency is known as epistasis. In recent years, there has
Júlia Domingo +2 more
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Proteins: Structure, Function, and Bioinformatics, 2021
Deep mutational scanning (DMS) facilitates data‐driven models of protein structure and function. Here, we adapted Saturated Programmable Insertion Engineering (SPINE) as a programmable DMS technique.
David Nedrud +2 more
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Deep mutational scanning (DMS) facilitates data‐driven models of protein structure and function. Here, we adapted Saturated Programmable Insertion Engineering (SPINE) as a programmable DMS technique.
David Nedrud +2 more
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Introducing Heuristic Information Into Ant Colony Optimization Algorithm for Identifying Epistasis
IEEE/ACM Transactions on Computational Biology & Bioinformatics, 2020Epistasis learning, which is aimed at detecting associations between multiple Single Nucleotide Polymorphisms (SNPs) and complex diseases, has gained increasing attention in genome wide association studies. Although much work has been done on mapping the
Yingxia Sun +5 more
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New Horizons for Dissecting Epistasis in Crop Quantitative Trait Variation.
Annual Review of Genetics, 2020Uncovering the genes, variants, and interactions underlying crop diversity is a frontier in plant genetics. Phenotypic variation often does not reflect the cumulative effect of individual gene mutations.
Sebastian Soyk +2 more
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Epistasis in Neuropsychiatric Disorders
Trends in Genetics, 2017The contribution of epistasis to human disease remains unclear. However, several studies have now identified epistatic interactions between common variants that increase the risk of a neuropsychiatric disorder, while there is growing evidence that genetic interactions contribute to the pathogenicity of rare, multigenic copy-number variants (CNVs) that ...
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Pleiotropy, epistasis and the genetic architecture of quantitative traits
Nature reviews geneticsT. Mackay, R. Anholt
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