Results 171 to 180 of about 132,877 (191)

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

Placental RTN3L‐dependent ER‐Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress

Advanced Science, EarlyView.
Gestational environmental stress activates ER‐phagy by increasing placental Rtn3l mRNA N6‐methyladenosine modification, further inhibiting placental estradiol synthesis and contributing to fetal testicular dysplasia. This study demonstrates the early prevention and treatment of adult male infertility from the perspective of fetal‐derived diseases ...
Ye‐Xin Luo, Hua‐Long Zhu, Bin‐Bin Huang, Cheng‐Fang Sun, Xin‐Xin Zhang, Xin‐Run Wang, Yi‐Fan Hu, Xu‐Dong Zhang, Shen‐Dong Xu, Huan Zhou, Rui Pan, Wei Chang, Zhi Yuan, Yong‐Wei Xiong, Xiao‐Feng Xu, Ling‐Li Zhao, De‐Xiang Xu, Hua Wang   +17 more
wiley   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1

Advanced Science, EarlyView.
The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong, Zhenling Wang, Yong Wang, Yang Chen, Hongqiang Zhang, Yunfei Lu, Lei Xu, Hengyang Shen, Changzhi Huang, Min Zhao, Wenjie Li, Shuai Wang, Yu Shao, Zan Fu   +13 more
wiley   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source