Results 81 to 90 of about 351,513 (313)

MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney tubules, renal vesicles, comma- and s-shaped bodies in human kidney

European Journal of Histochemistry, 2012
MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features.
V. Fanos, G. Faa, S. Mellou, G. Monga, P. Van Eyken, S. Nemolato, C. Gerosa, A. Locci, N. Iacovidou, D. Fanni   +9 more
doaj   +2 more sources

Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response

, 2019
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate ...
Bocci, Federico, Deng, Youyuan, Jia, Dongya, Jolly, Mohit Kumar, Levine, Herbert, Li, Xuefei, Onuchic, Jose N., Tripathi, Shubham   +7 more
core   +1 more source

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources

Additional file 1: of Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelialâ mesenchymal transition

, 2019
The ARRIVE Guidelines Checklist S1. Animal Research: Reporting In Vivo Experiments. (DOCX 623 kb)
Wang, Caihua, Shao, Liming, Pan, Chi, Ye, Jun, Ding, Zonghui, Wu, Jia, Du, Qin, Ren, Yuezhong, Zhu, Chunpeng   +8 more
openaire   +1 more source

MST4 Predicts Poor Prognosis And Promotes Metastasis By Facilitating Epithelial-Mesenchymal Transition In Gastric Cancer.

Cancer management and research, 2019
Metastasis is the main cause for gastric cancer (GC)-related deaths. Better understanding of GC metastatic mechanism would provide novel diagnostic markers and therapeutic targets. Though it has been reported that mammalian sterile-20-like kinase 4 (MST4) exerts the oncogenic role in other tumors, the prognostic value and biological role of MST4 in GC ...
Li,Taiyuan, Deng,Li, He,Xin, Jiang,Gongan, Hu,Fang, Ye,Shanping, You,Yu, Duanmu,Jinzhong, Dai,Hua, Huang,Guodong, Tang,Cheng, Lei,Xiong   +11 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Additional file 2: of Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelialâ mesenchymal transition

, 2019
Supplementary materials, methods, figures and tables. (DOCX 30583 kb)
Wang, Caihua, Shao, Liming, Pan, Chi, Ye, Jun, Ding, Zonghui, Wu, Jia, Du, Qin, Ren, Yuezhong, Zhu, Chunpeng   +8 more
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Epithelial-mesenchymal transition as strategic microenvironment mimicry for cancer cell survival and immune escape?

Genes and Diseases, 2017
Epithelial-mesenchymal transition (EMT) is the phenotypic transition of epithelial cells to mesenchymal cells characterized by loss of epithelial markers, loss of intercellular adherence and acquirement of mesenchymal cell markers and increased ...
Jun-Hui Qin, Li Wang, Qin-Long Li, Yuan Liang, Zhen-Yu Ke, Rui-An Wang   +5 more
doaj   +1 more source