Results 171 to 180 of about 2,769,274 (304)

Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis. [PDF]

Cancer Metastasis Rev
Wang X, Zhang CX, Zhao Y, He J, Thiery JP.   +4 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Epithelial-mesenchymal transition in cutaneous fibrosis disease: from mechanisms to therapy. [PDF]

Front Immunol
Yuan S, Luo Z, Yang N, Xiong T, Chen Y, Jian X, Wang Y, Xiao S, Chen J, Deng C.   +9 more
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Aldose Reductase Mediated Mitophagy Promotes Epithelial-Mesenchymal Transition of Hepatocytes [PDF]

Jingjing Yan,1 Wenke Zhao,1 Haoyu Wang,1 Lutan Zhou,1 Xianwei Li,1 Guannan Wang2 1Department of Pharmacy, Wannan Medical College, Wuhu, Anhui, 241002, People’s Republic of China; 2Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhou L, Li X, Yan J, Zhao W, Wang G, Wang H   +5 more
core  

Role of epithelial-mesenchymal transition (EMT) in malignancies: current status and future prospects. [PDF]

Signal Transduct Target Ther
Meftahpour V, Dakal TC, Maciaczyk J, Sharma A, Schmidt-Wolf IGH.   +4 more
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Clinicopathological Significance of Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma. [PDF]

Int J Mol Sci
Lequerica-Fernández P, Vallina-Fernández-Kelly C, Rodrigo JP, López-Pintor RM, Torres-Rivas HE, Rodríguez-Santamarta T, Blanco-Lorenzo V, Álvarez Teijeiro S, García-Pedrero JM, de Vicente JC.   +9 more
europepmc   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

Epithelial-to-mesenchymal transition in breast cancer: a role for insulin-like growth factor I and insulin-like growth factor–binding protein 3?

, 2015
Hanna A Zielinska,1 Amit Bahl,2 Jeff MP Holly,1 Claire M Perks1 1IGFs and Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, UK; 2Department of Clinical Oncology,
Perks CM, Bahl A, Holly JMP, Zielinska HA   +3 more
core