Results 231 to 240 of about 208,684 (264)

Epithelial-mesenchymal transition

Cell
Epithelial-mesenchymal transition (EMT) is a fundamental mechanism involved in the morphogenesis of metazoans. Through this evolutionarily conserved multi-stage process, cells acquire quasi-epithelial to multiple intermediate morphologies with epithelial and mesenchymal attributes, rarely reaching a complete mesenchymal phenotype.
Ruby Yun-Ju Huang, Guojun Sheng, Jean Paul Thiery   +2 more
exaly   +3 more sources

Epithelial–mesenchymal transition in the skin

Journal of Dermatological Science, 2011
Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, and malignant cutaneous cancers ...
Motonobu, Nakamura, Yoshiki, Tokura
openaire   +2 more sources

Epithelial-mesenchymal transition in the liver

Gastroentérologie Clinique et Biologique, 2010
Epithelial-mesenchymal transition (EMT) is a physiological process occurring in the embryo. In adult organism, EMT could be involved in disease development. In the liver, the possibility that EMT of liver epithelial cells participate to liver fibrosis is increasingly discussed.
D. Firrincielia, b, M. Boissana, b, c, N. Chignard   +5 more
openaire   +2 more sources

Molecular mechanisms of epithelial–mesenchymal transition [PDF]

Nature Reviews Molecular Cell Biology, 2014
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression.
, Rik Derynck, Derynck Rik
exaly   +5 more sources

EPITHELIAL MESENCHYMAL TRANSITION

2022
An epithelial-mesenchymal transition (EMT) is a biologic process that allows a polarized epithelial cell, which normally interacts with basement membrane via its basal surface, to undergo multiple biochemical changes that enable it to assume a mesenchymal cell phenotype, which includes enhanced migratory capacity, invasiveness, elevated resistance to ...
Dr. Mahalingam Bhuvaneswari, Dr. Sathish Muthukumar, Dr. Merlin Jayaraj   +2 more
openaire   +1 more source

Epithelial–mesenchymal transition in ovarian cancer

Cancer Letters, 2010
Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy. Hence, and understanding of the molecular changes associated with ovarian cancer metastasis could lead to the identification of targets for novel therapeutic interventions. The conversion of an epithelial cell to a mesenchymal cell plays a key role
Vergara D, Merlot B, Lucot JP, Collinet P, Vinatier D, Fournier I, Salzet M.   +6 more
openaire   +3 more sources

SERPINB3 induces epithelial–mesenchymal transition

The Journal of Pathology, 2010
AbstractEpithelial–mesenchymal transition is believed to facilitate invasion and metastasis formation of epithelial tumour cells. SERPINB3 is a serine protease inhibitor, physiologically found in normal squamous epithelium but over‐expressed in epithelial tumours and known to inhibit apoptosis.
QUARTA, SANTINA MARIA, VIDALINO, LAURA, TURATO C, RUVOLETTO, MARIAGRAZIA, CALABRESE, FIORELLA, VALENTE, MARIALUISA, CANNITO S, FASSINA G, PAROLA M, GATTA, ANGELO, PONTISSO, PATRIZIA   +10 more
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Epithelial-Mesenchymal Transitions in Cancer Progression

Cells Tissues Organs, 1996
Epithelial cells are the most important cell type in the development of human malignancies. More than 90% of all malignant tumors are carcinomas, and thus of epithelial origin. Aberrant growth and the ability to invade the underlying tissues are intrinsic properties of the fatally altered cells.
C, Birchmeier, W, Birchmeier, B, Brand-Saberi   +2 more
openaire   +2 more sources

Induction and regulation of epithelial–mesenchymal transitions

Biochemical Pharmacology, 2000
Herein we discuss the factors that bring about the transformation of epithelial cells into cells of fibroblastic phenotype. This type of transformation, referred to as epithelium-to-mesenchyme transition (EMT), allows cells to dissociate from the epithelial tissue from which they originate and to migrate freely.
B, Boyer, A M, Vallés, N, Edme
openaire   +2 more sources

Epithelial–mesenchymal transitions in development and pathologies

Current Opinion in Cell Biology, 2003
The epithelial-mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms. This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma. The molecular mechanisms of EMT were primarily studied in epithelial cell lines, leading to the discovery of ...
openaire   +2 more sources