Results 271 to 280 of about 2,769,274 (304)

Epithelial–mesenchymal transition in ovarian cancer

Cancer Letters, 2010
Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy. Hence, and understanding of the molecular changes associated with ovarian cancer metastasis could lead to the identification of targets for novel therapeutic interventions. The conversion of an epithelial cell to a mesenchymal cell plays a key role
Vergara D, Merlot B, Lucot JP, Collinet P, Vinatier D, Fournier I, Salzet M.   +6 more
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Molecular mechanisms of epithelial–mesenchymal transition [PDF]

Nature Reviews Molecular Cell Biology, 2014
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression.
Rik Derynck
exaly   +5 more sources

Epithelial-mesenchymal transition

Cell
Epithelial-mesenchymal transition (EMT) is a fundamental mechanism involved in the morphogenesis of metazoans. Through this evolutionarily conserved multi-stage process, cells acquire quasi-epithelial to multiple intermediate morphologies with epithelial and mesenchymal attributes, rarely reaching a complete mesenchymal phenotype.
Cecilia Xi, Zhang, Ruby Yun-Ju, Huang, Guojun, Sheng, Jean Paul, Thiery   +3 more
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Epithelial-Mesenchymal Transitions in Cancer Progression

Cells Tissues Organs, 1996
Epithelial cells are the most important cell type in the development of human malignancies. More than 90% of all malignant tumors are carcinomas, and thus of epithelial origin. Aberrant growth and the ability to invade the underlying tissues are intrinsic properties of the fatally altered cells.
C, Birchmeier, W, Birchmeier, B, Brand-Saberi   +2 more
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SERPINB3 induces epithelial–mesenchymal transition

The Journal of Pathology, 2010
AbstractEpithelial–mesenchymal transition is believed to facilitate invasion and metastasis formation of epithelial tumour cells. SERPINB3 is a serine protease inhibitor, physiologically found in normal squamous epithelium but over‐expressed in epithelial tumours and known to inhibit apoptosis.
QUARTA, SANTINA MARIA, VIDALINO, LAURA, TURATO C, RUVOLETTO, MARIAGRAZIA, CALABRESE, FIORELLA, VALENTE, MARIALUISA, CANNITO S, FASSINA G, PAROLA M, GATTA, ANGELO, PONTISSO, PATRIZIA   +10 more
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Epithelial-mesenchymal transition in pediatric nephropathies

Pathology - Research and Practice, 2016
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells may express mesenchymal cell markers with subsequent change in their functions, and it may be part of the etiopathogenesis of kidney disease.The aim of this study was to evaluate the immunexpression of some EMT inducers and markers in frequent nephropathies in pediatric ...
Laura Penna, Rocha, Samuel Cavalcante, Xavier, Fernanda Rodrigues, Helmo, Juliana Reis, Machado, Fernando Silva, Ramalho, Marlene Antônia, Dos Reis, Rosana Rosa Miranda, Corrêa   +6 more
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Induction and regulation of epithelial–mesenchymal transitions

Biochemical Pharmacology, 2000
Herein we discuss the factors that bring about the transformation of epithelial cells into cells of fibroblastic phenotype. This type of transformation, referred to as epithelium-to-mesenchyme transition (EMT), allows cells to dissociate from the epithelial tissue from which they originate and to migrate freely.
B, Boyer, A M, Vallés, N, Edme
openaire   +2 more sources

The role of SUMOylation in epithelial-mesenchymal transition

Journal of Molecular Medicine
Tumor metastasis remains a leading cause of mortality in cancer patients. The epithelial-mesenchymal transition (EMT) is pivotal for the invasion and metastasis of cancer cells, facilitating the transformation from epithelial to mesenchymal phenotypes and thereby altering cellular morphology and function.
Shujing Li, Xiaomin Yu, Lei Liang, Yang Zheng   +3 more
openaire   +2 more sources

Epithelial–mesenchymal transitions in tumour progression

Nature Reviews Cancer, 2002
Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression.
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Epithelial–mesenchymal transitions in development and pathologies

Current Opinion in Cell Biology, 2003
The epithelial-mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms. This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma. The molecular mechanisms of EMT were primarily studied in epithelial cell lines, leading to the discovery of ...
openaire   +2 more sources