Results 61 to 70 of about 2,769,274 (304)

Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer [PDF]

, 2012
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are ...
Dunning-Foreman, NL
core  

The mechanisms of colorectal cancer cell mesenchymal–epithelial transition induced by hepatocyte exosome-derived miR-203a-3p

Journal of Bio-X Research, 2018
. Phosphatase of regenerating liver 3 (PRL3) promotes colorectal cancer (CRC) metastasis by inducing epithelial-to-mesenchymal transition. Mesenchymal-to-epithelial transition (MET), the opposite of epithelial-to-mesenchymal transition, has been proposed
Heyang Xu, MD, Yongliang Huang, MD, Qiusheng Lan, MD, Yang Zhang, MD, Yujie Zeng, PhD, Tao Zhang, BA, Chisheng Chen, MD, Pengwei Su, BA, Ziqiang Chu, BA, Wei Lai, MD, Zhonghua Chu, MD   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21(Cip1) or Rb status [PDF]

, 2008
Melville Trust for the Care and Cure of Cancer to SP and SS.Background: TGF beta has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT).
Sharon Sheahan, Harrison David J, Harland, Stephen N., David J Harrison, Prost Sandrine, Sandrine Prost, Stephen N Hartland, Bellamy, Christopher O., Harland Stephen N, Christopher O Bellamy, Sheahan Sharon, Sheahan, Sharon, Bellamy Christopher O, Prost, Sandrine, Harrison, David J.   +14 more
core   +2 more sources

Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report

, 2023
Carcinosarcomas are endometrial neoplasms with malignant epithelial and mesenchymal components. These are rare tumors, corresponding to
Ana Camila Xavier Lopes, Yago Eloy Souza Barbosa, Camila Delfino Chaves, Marcelo Leite Vieira Costa, Renato Mazon Lima Verde Leal, Régis Ponte Conrado   +5 more
core   +1 more source

MicroRNAs as regulators of epithelial-mesenchymal transition [PDF]

Cell Cycle, 2008
Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the promotion of tumor invasion and metastasis.
Gregory, P., Bracken, C., Bert, A., Goodall, G.   +3 more
openaire   +3 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney tubules, renal vesicles, comma- and s-shaped bodies in human kidney

European Journal of Histochemistry, 2012
MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features.
V. Fanos, G. Faa, S. Mellou, G. Monga, P. Van Eyken, S. Nemolato, C. Gerosa, A. Locci, N. Iacovidou, D. Fanni   +9 more
doaj   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

MiR-21 is Required for the Epithelial–Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells [PDF]

, 2021
Breast cancer (BCa) is one of the leading health problems among women. Although significant achievements have led to advanced therapeutic success with targeted therapy options, more efforts are required for different subtypes of tumors and according to ...
Uysal-Onganer, Pınar, ARISAN, ELİF DAMLA, Miralles Arenas, Francesc, Sigrun Lange, Lange, S, Cieza-Borrella, CI, Cieza-Borrella, Clara, Rencuzogullari, O., Dwek, M, Lange, Sigrun, Dwek, Miriam, Uysal Onganer, P., RENCÜZOĞULLARI, ÖZGE, Miriam Dwek, Miralles Arenas, F, Miralles Arenas, F., Pinar Uysal-Onganer, Arisan, E., Francesc Miralles Arenas, Lange, S., Arisan, ED, Ozge Rencuzogullari, Rencuzogullari, O, Elif Damla Arisan, Clara Cieza-Borrella, Uysal-Onganer, P   +25 more
core   +1 more source