Results 81 to 90 of about 2,769,274 (304)

High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells. [PDF]

, 2011
Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis.
Friedman, N, Oliver Eickelberg, Yu, H, Richards, T., Kaplan, Tommy, Yingze Zhang, Kaplan, T, Pandit, Kusum V., Zhang, Y., Kusum V. Pandit, Richards, Thomas, Benos, Panayiotis V., Zeng, Q, Bais, A.S., Pandit, K.V., Kaminski, N., Handley, D, Bais, Abha S, Richards, T, Panayiotis V. Benos, Handley, Daniel, Richards Thomas, Haiying Yu, Bais, AS, Eickelberg, O, Benos, PV, Nir Friedman, Handley, D., Tommy Kaplan, Friedman, N., Pandit, Kusum V, Zeng, Q., Zhang, Yingze, Abha S Bais, Eickelberg, O., Kusum V Pandit, Bais Abha S., Zeng, Qilu, Yu, Haiying, Panayiotis V Benos, Kaplan, T., Eickelberg Oliver, Kaminski, N, Benos, Panayiotis V, Benos, P.V., Thomas Richards, Eickelberg, Oliver, Naftali Kaminski, Zeng Qilu, Daniel Handley, Pandit, KV, Bais, Abha S., Zhang, Y, Yu Haiying, Kaminski, Naftali, Yu, H., Qilu Zeng, Kaminski Naftali, Benos Panayiotis V., Handley Daniel, Friedman, Nir, Pandit Kusum V., Zhang Yingze, Kaplan Tommy, Friedman Nir, Abha S. Bais   +65 more
core   +1 more source

MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model

Molecular Therapy: Nucleic Acids, 2019
Lung epithelial-mesenchymal transition (EMT) plays an important role in silicosis fibrosis. The reverse process of EMT is mesenchymal-epithelial transition (MET), which is viewed as an anti-EMT therapy and is a good target toward fibrosis.
Jingping Sun, Qiuyue Li, Ximeng Lian, Zhonghui Zhu, Xiaowei Chen, Wanying Pei, Siling Li, Ali Abbas, Yan Wang, Lin Tian   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives [PDF]

, 2014
Antonio Díaz-López,1 Gema Moreno-Bueno,1,2 Amparo Cano11Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM ...
Moreno-Bueno G, Díaz-López, Antonio, Cano, Amparo, Moreno-Bueno, Gema, Moreno Bueno, Gema, Díaz-López A, Cano A   +6 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Loss of breast epithelial marker hCLCA2 promotes epithelial to mesenchymal transition and indicates higher risk of metastasis [PDF]

, 2011
Transition between epithelial and mesenchymal states is a feature of both normal development and tumor progression. We report that expression of chloride channel accessory protein hCLCA2 is a characteristic of epithelial differentiation in the ...
S A Mani, Yu, Y., Rao, K., R C Elble, Elble, R., Walia, V., J Cheng, Hollier, B.G., Y Yu, B G Hollier, J R McLean, Sun, M., M Sun, Cao, D., McLean, J.R., Mani, S.A., D Cao, Premkumar, L., V Walia, L Premkumar, K Rao, Cheng, J.   +21 more
core   +1 more source

TGF-β₁ induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids

Respiratory Research, 2009
Background Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling are poorly understood, and there is increasing evidence that even aggressive anti-inflammatory therapy ...
Zuraw Bruce L, Doerner Astrid M
doaj   +1 more source

Helicobacter pylori initiates a mesenchymal transition through ZEB1 in gastric epithelial cells. [PDF]

PLoS ONE, 2013
Chronic Helicobacter pylori infection provokes an inflammation of the gastric mucosa, at high risk for ulcer and cancer development. The most virulent strains harbor the cag pathogenicity island (cagPAI) encoding a type 4 secretion system, which allows ...
Jessica Baud, Christine Varon, Sandrine Chabas, Lucie Chambonnier, Fabien Darfeuille, Cathy Staedel   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Fallacy of Epithelial Mesenchymal Transition in Neoplasia [PDF]

Cancer Research, 2005
Abstract Epithelial mesenchymal transition has been postulated as a versatile mechanism which facilitates cellular repositioning and redeployment during embryonic development, tissue reconstruction after injury, carcinogenesis, and tumor metastasis.
David, Tarin, Erik W, Thompson, Donald F, Newgreen   +2 more
openaire   +2 more sources