Results 91 to 100 of about 2,769,274 (304)

Multifaceted Approaches in Epithelial Cell Adhesion Molecule-Mediated Circulating Tumor Cell Isolation

Molecules
Circulating tumor cells (CTCs) are pivotal in cancer metastasis and serve as valuable biomarkers for diagnosis, prognosis, and treatment monitoring. Traditional CTC capture methods predominantly utilize the epithelial cell adhesion molecule (EpCAM) as a ...
Dora Szerenyi, Gabor Jarvas, Andras Guttman   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mesenchymal to epithelial transition in development and disease

, 2007
Cellular plasticity is fundamental to embryonic development. The importance of cellular transitions in development is first apparent during gastrulation when the process of epithelial to mesenchymal transition transforms polarized epithelial cells into ...
Christine L. Chaffer, Chaffer, C.L., Erik W. Thompson, Thompson, E.W., Elizabeth D. Williams, Williams, E.D.   +5 more
core   +1 more source

Breast neoplasm epithelial-mesenchymal transition and cytokines: a systematic review

Cancer Cell International
A crucial aspect of the association involving inflammation and the development of cancer is the ability of cancer cells to undergo a transition into mesenchymal cells. The process is referred to as epithelial-mesenchymal transition (EMT).
Yian Chen, Haining Ding, Jiaqing Song, Xiufei Gao   +3 more
doaj   +1 more source

An angiotensin system inhibitor (losartan) potentiates antitumor efficacy of cisplatin in a murine model of non–small cell lung cancerCentral MessagePerspective

JTCVS Open
Objective: Previous studies have demonstrated synergistic antitumor effects of angiotensin system inhibition (ASI) combined with cisplatin therapy in pancreatic cancer.
Hexiao Tang, MD, PhD, Eric Abston, MD, PhD, Mozhdeh Sojoodi, PhD, Yongtao Wang, PhD, Derek J. Erstad, MD, Zenan Lin, MD, Bryan C. Fuchs, PhD, Kenneth K. Tanabe, MD, Michael Lanuti, MD   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Epithelial-mesenchymal feedback signalling during vertebrate organogenesis : genetic analysis of BMP-Gremlin1 antagonistic interactions [PDF]

, 2010
Branching morphogenesis of the metanephric kidney relies on an intricate molecular system that controls a highly regulated developmental program. Metanephric kidney organogenesis involves a complex system of epithelial mesenchymal interactions that ...
Gonçalves, Alexandre
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epithelial–Mesenchymal Transition in Acute Leukemias

International Journal of Molecular Sciences
Epithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for the differentiation of many tissues and organs.
Lokman Varisli, Spiros Vlahopoulos
openaire   +4 more sources

UBR5 regulates the progression of colorectal cancer cells through Snail-induced epithelial–mesenchymal transition

Genes and Diseases
Snail is a core inducer of epithelial-to-mesenchymal transition. Here, we show that UBR5 promotes ubiquitin-mediated degradation of Snail and regulates the progression of colorectal cancer cells through its E3 ubiquitin ligase function. UBR5 specifically
Xinyue Zhao, Ruiying Liu, Zhihui Han, Zehao Li, Ling Mei, Yuyang Liu, Xueqi Fu, Yue Jin   +7 more
doaj   +1 more source