Results 111 to 120 of about 208,684 (264)

Tracing the origin of myofibroblasts in kidney fibrosis

Nature Communications
Kidney fibrosis is a key pathological feature of chronic kidney disease (CKD), characterized by the activation and accumulation of αSMA-positive myofibroblasts.
Shun He, Tianchang Xia, Zhihou Guo, Xin Song, Haichang Wang, Haojie He, Ke Jia, Raodan Chen, Bin Zhou, Lingjuan He   +9 more
doaj   +1 more source

HOF‐Stabilized Apple EV Nanocargo in an NIR‐Responsive Hydrogel Enables On‐Demand Therapeutic Modulation for Transdermal Deep‐Joint Osteoarthritis Therapy

Advanced Healthcare Materials, EarlyView.
An NIR‐responsive transdermal hydrogel integrating apple EV nanocargo, berberine, piperine, HOFs, and graphene oxide enables localized osteoarthritis modulation. The platform supports enhanced transdermal delivery together with mild hyperthermia‐associated and redox‐related responses, leading to reduced inflammation and oxidative stress, improved ...
Yu‐Wen Tseng, Pei‐Wei Weng, Hsien‐Tsung Lu, Jiunn‐Horng Kang, Lekha Rethi, Lekshmi Rethi, Yan‐Ting Chen, Hieu Trung Nguyen, Yao‐Tung Tsai, Andrew E.‐Y. Chuang   +9 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Mesenchymal to epithelial transition (MET) in cancer progression: insights from logical modeling

Scientific Reports
The ability of carcinoma cells to transition along the epithelial-mesenchymal spectrum is crucial for metastasis. While the process of Epithelial to Mesenchymal Transition (EMT) has widely been studied, its reverse, Mesenchymal to Epithelial Transition ...
Sophia Orozco-Ruiz, Marco Ruscone, Emmanuel Barillot, Olivier Destaing, Laurence Calzone   +4 more
doaj   +1 more source

Gellan Gum Fluid Gel System for Controlled‐Delivery of Cytokine‐Licensed MSC‐EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency

Advanced Healthcare Materials, EarlyView.
Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh, Ava Dashti, Thomas E. Robinson, Robyn Gaffey, Richard Moakes, Neil Lagali, Liam Grover, Thomas Ritter   +7 more
wiley   +1 more source

A Lightweight, 3D‐Printable, Low‐Cost, “One‐Click” Dorsal Skin Window for High‐Quality Long‐Term Multimodal Subcutaneous Tumor Imaging

Advanced Healthcare Materials, EarlyView.
An innovative, lightweight 3D‐printed skinfold chamber system is presented for long‐term intravital imaging. This affordable, biocompatible platform simplifies surgical implantation and allows high‐resolution, multimodal visualization of the tumor microenvironment for up to four weeks.
Iván Cortés Domínguez, Xabier Morales Urteaga, Maider Esparza, Lucía Grande, Ainhoa Urbiola, Cristina Ederra, Tomas Muñoz Santoro, Beatrice Pinci, Alvaro Teijeira, Carlos Ortiz de Solórzano   +9 more
wiley   +1 more source

Pediatric cancer—pathology and microenvironment influence: a perspective into osteosarcoma and non-osteogenic mesenchymal malignant neoplasms

Discover Oncology
Pediatric cancer remains the leading cause of disease-related death among children aged 1–14 years. A few risk factors have been conclusively identified, including exposure to pesticides, high-dose radiation, and specific genetic syndromes, but the ...
Consolato M. Sergi
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

SnapShot: The Epithelial-Mesenchymal Transition

Cell, 2011
Sleeman, J. P., Thiery, J. P.
openaire   +3 more sources

N6-methyladenosine modification and post-translational modification of epithelial–mesenchymal transition in colorectal cancer

Discover Oncology
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Traditionally, colorectal cancer has been recognized as a disease caused by genetic mutations.
Yingnan Wang, Yufan Chen, Miaomiao Zhao
doaj   +1 more source