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Cadherins and Epithelial-to-Mesenchymal Transition
2013Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells are transcriptionally reprogrammed, resulting in decreased adhesion and enhanced migration or invasion. EMT occurs during different stages of embryonic development, including gastrulation and neural crest cell delamination, and is induced by a panel of specific transcription ...
Alexander, Gheldof, Geert, Berx
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The multiverse nature of epithelial to mesenchymal transition
Seminars in Cancer Biology, 2019 The epithelial mesenchymal transition (EMT) program is defined as a cellular transition from an epithelial to a mesenchymal state. This process occurs to provide the cell with new phenotypic assets and new skills to perform complex processes. EMT is regulated at multilayer levels, including transcriptional control of gene expression, regulation of RNA ...
Daniele Vergara +2 more
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Phosphate Toxicity and Epithelial to Mesenchymal Transition
2022The underlying role of inadequate or excess intake of phosphate is evident in disease states, including metabolic, skeletal, cardiac, kidney and various cancers. Elevated phosphate levels can induce epithelial to mesenchymal transition (EMT) and cell death.
Eric, Lewis +3 more
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Epigenetic Regulation of Epithelial to Mesenchymal Transition
Current Cancer Drug Targets, 2013Epithelial-mesenchymal transition (EMT) is a vital process implemented in embryo development, organ fibrosis, and cancer metastasis. Several transcription factors and signaling pathways impinge on the transcriptional program of the cell, leading to the change of cell phenotype without alteration of genotype.
Peiwei, Huangyang, Yongfeng, Shang
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Epithelial-to-Mesenchymal Transition in Renal Neoplasms
Advances in Anatomic Pathology, 2014Epithelial-to-mesenchymal transition (EMT) describes a phenotypical change induced in epithelial cells that lose their cell-cell basement membrane contacts and their structural polarity to become spindle-shaped and morphologically similar to mesenchymal/myofibroblast cell.
Huiying, He, Cristina, Magi-Galluzzi
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Polyamines modulate epithelial-to-mesenchymal transition
Amino Acids, 2011Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the genesis and progression of organ ...
Alessandra, Compagnone +13 more
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Epithelial-to-mesenchymal transition in tumor progression
Medical Oncology, 2017The epithelial-to-mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal state with invasive capacities. However, the EMT program is involved in both physiological and pathological processes.
Elena Prieto-García +3 more
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Epithelial to mesenchymal transition
Critical Care Medicine, 2012Anil K, Sharma, Rolf D, Hubmayr
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Evolutionary fingerprints of epithelial-to-mesenchymal transition
NatureMesenchymal plasticity has been extensively described in advanced epithelial cancers; however, its functional role in malignant progression is controversial1-5. The function of epithelial-to-mesenchymal transition (EMT) and cell plasticity in tumour heterogeneity and clonal evolution is poorly understood.
Luigi Perelli +35 more
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The many regulators of epithelial−mesenchymal transition
Nature Reviews Molecular Cell Biology, 2021Cameron Bracken, Gregory J Goodall
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