Results 71 to 80 of about 87,270,183 (304)

Mesenchymal to epithelial transition in development and disease

, 2007
Cellular plasticity is fundamental to embryonic development. The importance of cellular transitions in development is first apparent during gastrulation when the process of epithelial to mesenchymal transition transforms polarized epithelial cells into ...
Christine L. Chaffer, Chaffer, C.L., Erik W. Thompson, Thompson, E.W., Elizabeth D. Williams, Williams, E.D.   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.

PLoS ONE, 2014
Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers.
Yuanming Shen, Jiansong Zhou, Yang Li, Feng Ye, Xiaoyun Wan, Weiguo Lu, Xing Xie, Xiaodong Cheng   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer [PDF]

The FEBS Journal, 2017
Several lines of evidence indicate that during transformation epithelial cancer cells can acquire mesenchymal features via a process called epithelial‐to‐mesenchymal transition (EMT). This process endows cancer cells with increased invasive and migratory capacity, enabling tumour dissemination and metastasis.
Sciacovelli, M, Frezza, C
openaire   +2 more sources

'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells : modulation of the adherens junction complex by ketamine [PDF]

, 2013
Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however,
Claire E Hills, Hills Claire E., Jefferson Kieran P., Squires, Paul E., Issac K-K Liu, Tianrong Jin (452021), Jefferson, Kieran P., Liu, Kuo-Kang, Siamantouras Eleftherios, Siamantouras, Eleftherios, Claire E. Hills (452020), Hills, Claire E., Jin, Tianrong, Eleftherios Siamantouras, Paul E. Squires (452025), Jin Tianrong, Issac K-K Liu (452023), Squires Paul E., Tianrong Jin, Paul E Squires, Liu Issac K-K, Kieran P Jefferson, Kieran P. Jefferson (452024), Eleftherios Siamantouras (452022)   +23 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Noncoding RNAs in Tumor Epithelial‐to‐Mesenchymal Transition [PDF]

Stem Cells International, 2016
Epithelial‐derived tumor cells acquire the capacity for epithelial‐to‐mesenchymal transition (EMT), which enables them to invade adjacent tissues and/or metastasize to distant organs. Cancer metastasis is the main cause of cancer‐related death.
Ching-Wen Lin, Pei-Ying Lin, Pan-Chyr Yang   +2 more
openaire   +3 more sources

Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2 [PDF]

, 2006
Epithelial-to-mesenchymal transition (EMT) increases cell migration and invasion, and facilitates metastasis in multiple carcinoma types, but belies epithelial similarities between primary and secondary tumors.
CL Chaffer (21689666), ED Williams (9893567), JL Slavin (21765239), EW Thompson (14472741), JP Brennan (21764525), T Blick (13290234)   +5 more
core   +2 more sources

Epithelial-Mesenchymal Transition [PDF]

, 2008
The meeting was designed to explore the intersections of signalling networks regulating and supporting epithelial-mesenchymal (EMT) and mesenchymal-epithelial transitions (MET) in development, fibrosis, and cancer.
Thompson, Erik W., Muthuswamy, S. K., Thompson, E., Zavadil, J., Haley, J., Kalluri, R., Kalluri, Raghu, Zavadil, Jiri, Haley, John, Muthuswamy, Senthil K.   +9 more
core   +1 more source