Results 81 to 90 of about 274,446 (288)

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

Stem Cell Research, 2019
The aberrant regulation of the epithelial barrier integrity is involved in many diseases of the digestive tract, including inflammatory bowel diseases and colorectal cancer.
Marco Bardenbacher, Barbara Ruder, Nathalie Britzen-Laurent, Benjamin Schmid, Maximilian Waldner, Elisabeth Naschberger, Michael Scharl, Werner Müller, Claudia Günther, Christoph Becker, Michael Stürzl, Philipp Tripal   +11 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Multivalent Adhesion Molecule 7 Clusters Act as Signaling Platform for Host Cellular GTPase Activation and Facilitate Epithelial Barrier Dysfunction [PDF]

, 2014
Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract and can cause severe enteritis and bacteraemia. During infection, V.
Anne Marie Krachler, Charlie Anne Watson, Daniel H Stones, Watson, Charlie Anne, Hawley, Catherine Alice, Catherine Alice Hawley, Krachler, Anne Marie, Lim, Jenson, Stones, Daniel H, Jenson Lim   +9 more
core   +1 more source

Estrogen prevented gingival barrier injury from Porphyromonas gingivalis lipopolysaccharide

Infection and Immunity
The postmenopausal population usually suffers from more severe periodontal disease than non-menopausal women due to the decrease and low levels of estrogen, especially β-estradiol (E2).
Fangting Huang, Zhifei Su, Fangjie Zhou, Yajie Wu, Jiyao Li, Biao Ren   +5 more
doaj   +1 more source

The Role of Defective Epithelial Barriers in Allergic Lung Disease and Asthma Development

Journal of Asthma and Allergy, 2022
Nazek Noureddine,1– 3 Maciej Chalubinski,4 Paulina Wawrzyniak1,2 1Division of Clinical Chemistry and Biochemistry, University Children’s Hospital Zurich, Zurich, Switzerland; 2Children’s Research Center, University Children’s Hospital Zurich, Zurich ...
Noureddine N, Chalubinski M, Wawrzyniak P   +2 more
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Complexity and Redundancy of Epithelial Barrier Function [PDF]

The Journal of Cell Biology, 2000
Recent analyses of mummified or long-frozen human specimens have revealed that the outermost layer of our skin, the epidermis, is one of the most durable soft tissues of the body. The major function of the epidermis is to provide a protective barrier, and recent work now suggests that evolution ...
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Role of the Barrier Dysfunction of the Intestines in the Development of Alimentary Allergy in Children

Вопросы современной педиатрии, 2013
Intestinal epithelial barrier plays an important role in prevention of bacterial translocation and food allergens penetration. Article is dedicated to intestinal epithelial barrier disfunctions leading to sensitization.
T. E. Borovik, S. G. Makarova, G. V. Yatsyk, T. N. Stepanova, S. G. Gribakin   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source