Results 81 to 90 of about 921,216 (339)

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2*

Journal of Biological Chemistry, 2008
MicroRNAs are small non-coding RNA molecules that can regulate gene expression by interacting with multiple mRNAs and inducing either translation suppression or degradation of mRNA.
M. Korpal, Esther S. Lee, G. Hu, Yibin Kang   +3 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion

Frontiers in Immunology, 2018
Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance.
Steve Swain, Mandi M. Roe, Thomas A. Sebrell, Barkan Sidar, Jennifer Dankoff, Rachel VanAusdol, Lesley E. Smythies, Phillip D. Smith, Diane Bimczok   +8 more
doaj   +1 more source

WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. [PDF]

PLoS ONE, 2013
Epithelial morphogenesis is a dynamic process that involves coordination of signaling and actin cytoskeletal rearrangements.We analyzed the contribution of the branched actin regulator WAVE2 in the development of 3-dimensional (3D) epithelial structures.
Nicole S Bryce, Albert B Reynolds, Anthony J Koleske, Alissa M Weaver   +3 more
doaj   +1 more source

Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. [PDF]

, 2018
Mechanisms that sense and regulate epithelial morphogenesis, integrity, and homeostasis are incompletely understood. Protease-activated receptor 2 (Par2), the Par2-activating membrane-tethered protease matriptase, and its inhibitor, hepatocyte activator ...
Balouch, Eaman, Barker, Adrian, Clay, Hilary, Coughlin, Shaun R, Hsiao, Chung-Der, Lam, Ian, Schepis, Antonino, Srinivasan, Yoga, Zheng, Yaowu   +8 more
core   +1 more source

Truncated E‐cadherin potentiates cell death in prostate epithelial cells [PDF]

The Prostate, 2005
AbstractBACKGROUNDE‐cadherin, a fundamental component of the adherens junction, is known to mediate aggregation‐dependent cell survival. We have previously identified a novel, calpain‐dependent proteolytic cleavage of E‐cadherin that resulted in the generation of a stable 100‐kDa E‐cadherin fragment (E‐cad100) in prostate epithelial cells in response ...
Rios-Doria, Jonathan, Day, Mark L.
openaire   +3 more sources

Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine

Toxins, 2019
Clostridium perfringens strains B and C cause fatal intestinal diseases in animals. The secreted pore-forming toxin delta-toxin is one of the virulence factors of the strains, but the mechanism of intestinal pathogenesis is unclear. Here, we investigated
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama   +3 more
doaj   +1 more source

Immunohistochemical expression of E-cadherin and N-cadherin in endometrioid endometrial carcinoma and its precursor lesions

Clinical Epidemiology and Global Health, 2023
Objectives: Endometrial carcinoma (EC), majority being endometroid endometrial carcinoma (EEC), is the most common invasive gynecological cancer world-wide.
Sunita Yadav, Annu Makkar, Preeti Agarwal, Uma Singh, Uma Shankar Singh, Madhu Mati Goel   +5 more
doaj   +1 more source

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]

, 2018
The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker, Barbaresi, Barton, Belleudi, Boukamp, Brooks, Candi, Capone, Chaffer, Dotto, Feng, Gaggioli, Getsios, Goetz, Grose, Harmon, Haugsten, Ishiwata, Izar, Jones, Kawase, Matsuda, Oh, Oltean, Peng, Petiot, Pickard, Pickard, Purpura, Raffa, Ramsey, Ranieri, Ranieri, Shamir, Shih, Simpson, Truong, Turner, Warzecha, Warzecha, Yang, Ye, Zhang, Zhao   +43 more
core   +1 more source