Results 61 to 70 of about 131,334 (259)
SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium. [PDF]
PLoS ONE, 2014 Expression of the cellular adhesion protein N-cadherin is a critical event during epithelial-mesenchymal transition (EMT). The SMAD4 protein has been identified as a mediator of transforming growth factor-β (TGF-β) superfamily signaling, which regulates ...
Ya'an Kang +11 more
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Frontiers in Immunology, 2018 Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance.
Steve Swain +8 more
doaj +1 more source
Oncology Reviews, 2020 The metastatic process of ovarian cancer (OC) is almost exclusively defined by direct shedding of tumor cells into the abdominal cavity, followed by clustering into multicellular aggregates and posterior peritoneal anchorage.
Ricardo J. Roque +2 more
doaj +1 more source
E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo. [PDF]
PLoS Genetics, 2018 Cell polarity and correct mitotic spindle positioning are essential for the maintenance of a proper prostate epithelial architecture, and disruption of the two biological features occurs at early stages in prostate tumorigenesis. However, whether and how
Xue Wang +11 more
doaj +1 more source
Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium [PDF]
Developmental Dynamics, 1998 The cadherins are key morphoregulators. A switch in the cadherin subtype(s) expressed by a population of cells has been associated with the differentiation and formation of tissues during embryonic development. To date, the role(s) of the cadherins in the highly regulated remodeling processes which occur in the human endometrium in preparation for the ...
S, Getsios +5 more
openaire +2 more sources
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
P-Cadherin Expression in Feline Mammary Tissues
Veterinary Medicine International, 2012 The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans.
Ana Catarina Figueira +5 more
doaj +1 more source
Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine
Toxins, 2019 Clostridium perfringens strains B and C cause fatal intestinal diseases in animals. The secreted pore-forming toxin delta-toxin is one of the virulence factors of the strains, but the mechanism of intestinal pathogenesis is unclear. Here, we investigated
Soshi Seike +3 more
doaj +1 more source
WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. [PDF]
PLoS ONE, 2013 Epithelial morphogenesis is a dynamic process that involves coordination of signaling and actin cytoskeletal rearrangements.We analyzed the contribution of the branched actin regulator WAVE2 in the development of 3-dimensional (3D) epithelial structures.
Nicole S Bryce +3 more
doaj +1 more source