Results 61 to 70 of about 921,216 (339)

Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces [PDF]

Proceedings of the National Academy of Sciences, 2012
Cell–cell and cell–matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between these two adhesion types, yet little is known about the impact of these interactions on the mechanical coupling of cells to the extracellular matrix (ECM).
Aaron F, Mertz, Yonglu, Che, Shiladitya, Banerjee, Jill M, Goldstein, Kathryn A, Rosowski, Stephen F, Revilla, Carien M, Niessen, M Cristina, Marchetti, Eric R, Dufresne, Valerie, Horsley   +9 more
openaire   +3 more sources

Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]

, 2018
The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M, Barber, Diane L, Choi, Changhoon, Rana, Manish K   +3 more
core   +2 more sources

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]

, 2018
Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia, Bordoni, Veronica, DE TURRIS, Valeria, Domenici, Alessandro, Mai, Antonello, Manzione, Andrea, Mene', Paolo, Moioli, Alessandra, Noce, Valeria, Palladino, Marco, Rossi, Lucia, Strippoli, Raffaele, Tripodi, Marco, Valente, Sergio, Zwergel, Clemens   +14 more
core   +1 more source

Azaspiracid-1 Alters the E-cadherin Pool in Epithelial Cells [PDF]

Toxicological Sciences, 2006
Azaspiracids cause severe damages in the epithelium of several organs. In this study we have investigated the effects of azaspiracid-1 (AZA-1) on two epithelial cell lines. Nanomolar concentrations of AZA-1 reduced MCF-7 cell proliferation and impaired cell-cell adhesion. AZA-1 altered the cellular pool of the adhesion molecule E-cadherin by inducing a
RONZITTI, Giuseppe, HESS P, REHMANN N, ROSSINI, Gian Paolo   +3 more
openaire   +2 more sources

Molecular Tension Microscopy of E-Cadherin During Epithelial-Mesenchymal Transition [PDF]

, 2020
Molecular Tension Microscopy has been increasingly used in the last years to investigate mechanical forces acting in cells at the molecular scale. Here, we describe a protocol to image the tension of the junctional protein E-cadherin in cultured epithelial cells undergoing Epithelial-Mesenchymal Transition (EMT).
Canever, Helena, Carollo, Pietro Salvatore, Fleurisson, Romain, Girard, Philippe, Borghi, Nicolas   +4 more
openaire   +3 more sources

Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

Neoplasia: An International Journal for Oncology Research, 2008
E-cadherin is a main component of the cell-cell adhesion junctions that play a principal role in maintaining normal breast epithelial cell morphology. Breast and other cancers that have up-regulated activity of Ras are often found to have down-regulated ...
Quanwen Li, Raymond R. Mattingly
doaj   +1 more source

Cleavage of E-cadherin by porcine respiratory bacterial pathogens facilitates airway epithelial barrier disruption and bacterial paracellular transmigration

Virulence, 2021
Airway epithelial cells are the first line of defense against respiratory pathogens. Porcine bacterial pathogens, such as Bordetella bronchiseptica, Actinobacillus pleuropneumoniae, Glaesserella (Haemophilus) parasuis, and Pasteurella multocida, breach ...
Qi Cao, Wenbin Wei, Huan Wang, Zesong Wang, Yujin Lv, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang   +8 more
doaj   +1 more source

Patterns in Space: Coordinating Adhesion and Actomyosin Contractility at E-cadherin Junctions

, 2013
Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their biological actions through active cooperation with the contractile actin ...
Wu, Selwin K., Yap, Alpha S.
core   +1 more source

Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. [PDF]

, 2019
Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, has been shown to reduce pancreatic cancer growth, but its effect on
Hackman, Robert M, Mackenzie, Gerardo G, Penso, Natalia E Cortez, Wang, Yuefei, Wei, Ran   +4 more
core   +2 more sources

Collective cell migration: Implications for wound healing and cancer invasion. [PDF]

, 2013
During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration.
He, Yong, Jiang, Jianxin, Li, Li, Zhao, Min   +3 more
core   +2 more sources