Results 41 to 50 of about 921,216 (339)
E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. [PDF]
PLoS ONE, 2017 Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern.
Marina Rosso +16 more
doaj +1 more source
PALS1 Regulates E-Cadherin Trafficking in Mammalian Epithelial Cells [PDF]
Molecular Biology of the Cell, 2007 Protein Associated with Lin Seven 1 (PALS1) is an evolutionarily conserved scaffold protein that targets to the tight junction in mammalian epithelia. Prior work in our laboratory demonstrated that the knockdown of PALS1 in Madin Darby canine kidney cells leads to tight junction and polarity defects.
Qian, Wang +2 more
openaire +2 more sources
Interactions and Feedbacks in E-Cadherin Transcriptional Regulation
Frontiers in Cell and Developmental Biology, 2021 Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The transmembrane protein E-cadherin is the major protein that mediates homophilic adhesion between neighbouring cells and is, therefore, one of the critical ...
Miguel Ramirez Moreno +2 more
doaj +1 more source
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
core +2 more sources
E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors [PDF]
Cancers, 2021 Inactivating germline mutations in the CDH1 gene (encoding the E-cadherin protein) are the genetic hallmark of hereditary diffuse gastric cancer (HDGC), and somatic CDH1 mutations are an early event in the development of sporadic diffuse gastric cancer (DGC) and lobular breast cancer (LBC).
Lyvianne Decourtye-Espiard +6 more
openaire +2 more sources
PLoS Genetics, 2019 E-cadherin complexes with the actin cytoskeleton via cytoplasmic catenins and maintains the functional characteristics and integrity of the epithelia in normal epithelial tissues.
Adam Olson +10 more
doaj +1 more source
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source
Genes & Development, 2008 Cancer progression has similarities with the process of epithelial-to-mesenchymal transition (EMT) found during embryonic development, during which cells down-regulate E-cadherin and up-regulate Vimentin expression.
Sun-Mi Park +3 more
semanticscholar +1 more source
TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. [PDF]
, 2016 E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum ...
Barcellos-Hoff, MH +3 more
core +1 more source
Snail in the frame of malignant tumor recurrence [PDF]
, 2006 A
De Craene, Bram, Berx, Geert
core +2 more sources