Results 31 to 40 of about 127,439 (263)

The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression.

PLoS Genetics, 2019
E-cadherin complexes with the actin cytoskeleton via cytoplasmic catenins and maintains the functional characteristics and integrity of the epithelia in normal epithelial tissues.
Adam Olson, Vien Le, Joseph Aldahl, Eun-Jeong Yu, Erika Hooker, Yongfeng He, Dong-Hong Lee, Won Kyung Kim, Robert D Cardiff, Joseph Geradts, Zijie Sun   +10 more
doaj   +1 more source

Epithelial Viscoelasticity Is Regulated by Mechanosensitive E-cadherin Turnover [PDF]

Current Biology, 2019
Studying how epithelia respond to mechanical stresses is key to understanding tissue shape changes during morphogenesis. Here, we study the viscoelastic properties of the Drosophila wing epithelium during pupal morphogenesis by quantifying mechanical stress and cell shape as a function of time.
Iyer, K., Piscitello-Gómez, R., Paijmans, J., Jülicher, F., Eaton, S.   +4 more
openaire   +4 more sources

Expression of E-cadherin and N-cadherin in Epithelial-to-Mesenchymal Transition of Osteosarcoma: A Systematic Review

Cureus, 2023
Osteosarcoma (OS) is a debilitating cancer of the bone that commonly afflicts the young and old. This may be de novo or associated with tumorigenic syndromes. However, many molecular mechanisms are still being uncovered and may offer greater avenues for screening and therapy.
Issagholian, Leo, Tabaie, Ethan, Reddy, Akshay J, Ghauri, Muhammad S, Patel, Rakesh   +4 more
openaire   +2 more sources

GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells

Cell Reports, 2019
Summary: O-GalNAc glycosylation is initiated in the Golgi by glycosyltransferases called GALNTs. Proteomic screens identified >600 O-GalNAc-modified proteins, but the biological relevance of these modifications has been difficult to determine.
Deepthi Raghu, Robert J. Mobley, Noha A.M. Shendy, Charles H. Perry, Amy N. Abell   +4 more
doaj   +1 more source

E-Cadherin in Pancreatic Ductal Adenocarcinoma: A Multifaceted Actor during EMT

Cells, 2020
Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and tumor cells leading to a switch from epithelial to mesenchymal phenotype.
Michele Sommariva, Nicoletta Gagliano
doaj   +1 more source

ZEB1 is Negatively Correlated with E-Cadherin in Prostatic Anomaly Tissue

MCBS (Molecular and Cellular Biomedical Sciences), 2022
Background: Prostatic anomalies are common in tumor or infection condition. The enlargement of prostate gland affects the epithelial cell polarity that involves epithelial-mesenchymal transition (EMT).
Sari Eka Pratiwi, Sri Nuryani Wahyuningrum, Rachmagreta Perdana Putri, Danarto Danarto, Didik Setyo Heriyanto, Nur Arfian, Sofia Mubarika Haryana, Indwiani Astuti   +7 more
doaj   +1 more source

E‐Cadherin/β‐Catenin Complex and the Epithelial Barrier [PDF]

BioMed Research International, 2011
E‐Cadherin/β‐catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt‐signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial ...
Tian, Xinrui, Liu, Zhuola, Niu, Bo, Zhang, Jianlin, Tan, Thian Kui, Lee, So Ra, Zhao, Ye, Harris, David C. H., Zheng, Guoping   +8 more
openaire   +2 more sources

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling.

PLoS ONE, 2021
Cadherins control intercellular adhesion in most metazoans. In vertebrates, intercellular adhesion differs considerably between cadherins of type-I and type-II, predominantly due to their different extracellular regions.
Darwesh Mohideen Kaderbatcha Aladin, Yeh Shiu Chu, Shuo Shen, Robert Charles Robinson, Sylvie Dufour, Virgile Viasnoff, Nicolas Borghi, Jean Paul Thiery   +7 more
doaj   +1 more source

Azaspiracid-1 Alters the E-cadherin Pool in Epithelial Cells [PDF]

Toxicological Sciences, 2006
Azaspiracids cause severe damages in the epithelium of several organs. In this study we have investigated the effects of azaspiracid-1 (AZA-1) on two epithelial cell lines. Nanomolar concentrations of AZA-1 reduced MCF-7 cell proliferation and impaired cell-cell adhesion. AZA-1 altered the cellular pool of the adhesion molecule E-cadherin by inducing a
RONZITTI, Giuseppe, HESS P, REHMANN N, ROSSINI, Gian Paolo   +3 more
openaire   +2 more sources

Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

Neoplasia: An International Journal for Oncology Research, 2008
E-cadherin is a main component of the cell-cell adhesion junctions that play a principal role in maintaining normal breast epithelial cell morphology. Breast and other cancers that have up-regulated activity of Ras are often found to have down-regulated ...
Quanwen Li, Raymond R. Mattingly
doaj   +1 more source