Results 11 to 20 of about 127,439 (263)

Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells. [PDF]

PLoS ONE, 2012
Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations.We used cultures of freshly
Christof Keller, Sven Kroening, Jonathan Zuehlke, Frank Kunath, Bettina Krueger, Margarete Goppelt-Struebe   +5 more
doaj   +5 more sources

Significance and prognosis of epithelial-cadherin expression in invasive breast carcinoma. [PDF]

Oncol Lett, 2018
The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer.
Yang L, Wang XW, Zhu LP, Wang HL, Wang B, Zhao Q, Wang XY.   +6 more
europepmc   +4 more sources

Induction of entosis by epithelial cadherin expression [PDF]

Cell Research, 2014
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as ...
Qiang, Sun, Edmund S, Cibas, Hongyan, Huang, Louis, Hodgson, Michael, Overholtzer   +4 more
openaire   +2 more sources

E-cadherin on epithelial–mesenchymal transition in thyroid cancer [PDF]

Cancer Cell International, 2021
AbstractThyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets.
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng   +3 more
openaire   +3 more sources

Role of E-Cadherin in Epithelial Architecture Maintenance [PDF]

Cell Communication & Adhesion, 2010
Morphogenesis and architecture of a developing epithelium is controlled by both cell shape and contacts, mediated by spatially and temporally regulated cell adhesion molecules. The authors study if E-cadherin functions as a key factor of epithelial adhesion and epidermal architecture in vivo.
Izaguirre, María Fernanda, Larrea, D., Adur, Javier Fernando, Diaz Zamboni, Javier Eduardo, Vicente, N. B., Galetto, Carolina, Casco, Victor Hugo   +6 more
openaire   +3 more sources

Vangl2 Regulates E-Cadherin in Epithelial Cells [PDF]

Scientific Reports, 2014
E-cadherin belongs to the classic cadherin subfamily of calcium-dependent cell adhesion molecules and is crucial for the formation and function of epithelial adherens junctions. In this study, we demonstrate that Vangl2, a vertebrate regulator of planar cell polarity (PCP), controls E-cadherin in epithelial cells.
Nagaoka, Tadahiro, Inutsuka, Ayumu, Begum, Khadiza, hafiz, Khandakar musabbir bin, Kishi, Masashi   +4 more
openaire   +2 more sources

Cadherin and Integrin Regulation of Epithelial Cell Migration [PDF]

Langmuir, 2009
These studies quantified the relative effects of E-cadherin expression and homophilic ligation on the integrin-mediated motility of epithelial cells. Micropatterned proteins were used to quantitatively titrate the ligation of E-cadherin and integrin receptors in order to assess their coordinate influence on the migration velocities of MDA-MB-231 breast
Jonathan, Silvestre, Paul J A, Kenis, Deborah E, Leckband   +2 more
openaire   +2 more sources

Soluble E‐cadherin: A marker of genital epithelial disruption

American Journal of Reproductive Immunology, 2022
AbstractProblemThe genital epithelial barrier is a crucial first line of defence against HIV, and epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial integrity requires biopsies, but their collection is not practical in many research settings.
Rachel Liu, Eric Armstrong, Shirley Constable, Lane B Buchanan, Avid Mohammadi, Ronald M Galiwango, Sanja Huibner, Marie C Perry, Jessica L Prodger, Bryan Coburn, Rupert Kaul   +10 more
openaire   +2 more sources

CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion. [PDF]

PLoS ONE, 2011
E-cadherin is frequently lost during epithelial-mesenchymal transition and the progression of epithelial tumorigenesis. We found a marker of epithelial-mesenchymal transition, CD44, upregulated in response to functional loss of E-cadherin in esophageal ...
Grégoire F Le Bras, Gillian L Allison, Nicole F Richards, Shazia S Ansari, M Kay Washington, Claudia D Andl   +5 more
doaj   +1 more source

Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]

PLoS ONE, 2016
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly, James R Cooley, Sebastian L Zeltzer, Tatiana A Yatskievych, Parker B Antin   +4 more
doaj   +1 more source