Results 11 to 20 of about 921,216 (339)

Induction of entosis by epithelial cadherin expression [PDF]

Cell Research, 2014
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as ...
Qiang, Sun, Edmund S, Cibas, Hongyan, Huang, Louis, Hodgson, Michael, Overholtzer   +4 more
openaire   +3 more sources

Epithelial Viscoelasticity Is Regulated by Mechanosensitive E-cadherin Turnover [PDF]

Current Biology, 2019
Studying how epithelia respond to mechanical stresses is key to understanding tissue shape changes during morphogenesis. Here, we study the viscoelastic properties of the Drosophila wing epithelium during pupal morphogenesis by quantifying mechanical stress and cell shape as a function of time.
Iyer, K., Piscitello-Gómez, R., Paijmans, J., Jülicher, F., Eaton, S.   +4 more
openaire   +5 more sources

E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo. [PDF]

PLoS Genetics, 2018
Cell polarity and correct mitotic spindle positioning are essential for the maintenance of a proper prostate epithelial architecture, and disruption of the two biological features occurs at early stages in prostate tumorigenesis. However, whether and how
Xue Wang, Baijun Dong, Kai Zhang, Zhongzhong Ji, Chaping Cheng, Huifang Zhao, Yaru Sheng, Xiaoxia Li, Liancheng Fan, Wei Xue, Wei-Qiang Gao, Helen He Zhu   +11 more
doaj   +2 more sources

Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin

Journal of Circulating Biomarkers, 2018
Epithelial cell adhesion molecule (EpCAM)-targeted capture remains the most common isolation strategy for circulating tumor cells (CTCs). However, epithelial-to-mesenchymal transition (EMT) leads to decreased epithelial EpCAM expression affecting the ...
Joseph W Po, Aflah Roohullah, David Lynch, Anna DeFazio, Michelle Harrison, Paul R Harnett, Catherine Kennedy, Paul de Souza, Therese M Becker   +8 more
doaj   +2 more sources

Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

Respiratory Research, 2016
In acutely injured lungs, massively recruited polymorphonuclear neutrophils (PMNs) secrete abnormally neutrophil elastase (NE). Active NE creates a localized proteolytic environment where various host molecules are degraded leading to impairment of tissue homeostasis.
Boxio, Rachel, Wartelle, Julien, Nawrocki-Raby, Béatrice, Lagrange, Brice, Malleret, Laurette, Hirche, Timothee, Taggart, Clifford, Pacheco, Yves, Devouassoux, Gilles, Bentaher, Abderrazzaq   +9 more
openaire   +6 more sources

Epithelial cadherin distribution in abnormal human pre-implantation embryos [PDF]

Human Reproduction, 2005
E(epithelial)-cadherin is a vital cell adhesion protein that plays a critical role in morphogenesis. Previous studies of E-cadherin distribution in human embryos have produced equivocal results.Immunocytochemistry in conjunction with laser scanning confocal microscopy was used to detect E-cadherin in 97 human cleavage stage embryos and 35 blastocysts ...
M. Alikani
openaire   +3 more sources

Significance and prognosis of epithelial-cadherin expression in invasive breast carcinoma. [PDF]

Oncol Lett, 2018
The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics ...
Yang L, Wang XW, Zhu LP, Wang HL, Wang B, Zhao Q, Wang XY.   +6 more
europepmc   +2 more sources

Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Breast Cancer Research, 2017
Background Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epithelial transition (MET).
H. J. Hugo, N. P. A. D. Gunasinghe, B. G. Hollier, T. Tanaka, T. Blick, A. Toh, P. Hill, C. Gilles, M. Waltham, E. W. Thompson   +9 more
doaj   +2 more sources

E-cadherin on epithelial–mesenchymal transition in thyroid cancer [PDF]

Cancer Cell International, 2021
AbstractThyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets.
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng   +3 more
openaire   +3 more sources

CDH1 (cadherin 1, type 1, E-cadherin (epithelial)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), with data on DNA, on the protein encoded, and where the gene is implicated.
MF Calmon, P Rahal
openaire   +1 more source