Results 11 to 20 of about 131,334 (259)

Significance and prognosis of epithelial-cadherin expression in invasive breast carcinoma. [PDF]

Oncol Lett, 2018
The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer.
Yang L, Wang XW, Zhu LP, Wang HL, Wang B, Zhao Q, Wang XY.   +6 more
europepmc   +4 more sources

Cadherin-23 Mediates Heterotypic Cell-Cell Adhesion between Breast Cancer Epithelial Cells and Fibroblasts [PDF]

PLoS ONE, 2012
In the early stages of breast cancer metastasis, epithelial cells penetrate the basement membrane and invade the surrounding stroma, where they encounter fibroblasts.
Lee Ligon
exaly   +2 more sources

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges [PDF]

Cells, 2019
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients.
Chung Yeng Looi, Pei Pei Chong, Gautam Sethi   +2 more
exaly   +4 more sources

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance [PDF]

Nature Communications
Beyond serving as cohesive barriers, epithelia clear apoptotic cells to regulate development, homeostasis and inflammation. How epithelial cells remodel their shape during phagocytosis while preserving tissue integrity, and the role of adhesion receptors
Hanna-Maria Häkkinen, Marta Batet, Laura F. Bianchi, Senda Jiménez-Delgado, Fabio Pezzano, Stefan Wieser, Luca Ciampa, Esteban Hoijman, Carina Vibe, Sofie Wijma, Verena Ruprecht   +10 more
doaj   +2 more sources

Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells. [PDF]

PLoS ONE, 2012
Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations.We used cultures of freshly
Christof Keller, Sven Kroening, Jonathan Zuehlke, Frank Kunath, Bettina Krueger, Margarete Goppelt-Struebe   +5 more
doaj   +5 more sources

Analysis of the loss of Epithelial Cadherin expression in gastric cancer in Zambia. [PDF]

Med J Zambia
Background: Gastric cancer (GC) is the one of the most common cancers globally and can be classified as diffuse, intestinal or mixed. Epithelial-cadherin (E-cadherin) is a transmembrane glycoprotein which plays a role in maintaining cell shape and extracellular matrix and its loss or reduction has been observed in gastric carcinogenesis. The aim of the
Dokowe V, Songwe M, Mumba C, Kayamba V.
europepmc   +3 more sources

CC16 alleviates PM2.5-induced airway inflammation in asthmatic mice by targeting the E-cadherin-mediated ferroptosis regulatory axis [PDF]

Current Research in Toxicology
Airway epithelial ferroptosis is critically involved in PM2.5-driven asthmatic airway damage, and our previous studies have demonstrated the protective role of club cell protein 16 (CC16) against fine particulate matter (PM2.5)-induced airway ...
Aili Wang, Shuo Yang, Fang Xu, Jianling Liu, Jinle Lin, Jian Wu   +5 more
doaj   +2 more sources

Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis

Frontiers in Cellular and Infection Microbiology
Epithelial barriers serve as critical defense lines against microbial infiltration and maintain tissue homeostasis. E-cadherin, an essential component of adherens junctions, has emerged as a pivotal molecule that secures epithelial homeostasis.
Peter Lialios, Peter Lialios, Stella Alimperti, Stella Alimperti   +3 more
exaly   +3 more sources

Cadherin Expression and EMT: A Focus on Gliomas

Biomedicines, 2021
Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination.
Carolina Noronha, Ana Sofia Ribeiro, Ricardo Taipa, Diogo S. Castro, Joaquim Reis, Cláudia Faria, Joana Paredes   +6 more
doaj   +1 more source

A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. [PDF]

PLoS ONE, 2015
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells.
Svetlana N Rubtsova, Irina Y Zhitnyak, Natalya A Gloushankova   +2 more
doaj   +1 more source