Results 1 to 10 of about 921,216 (339)

Adherens Junction and E-Cadherin complex regulation by epithelial polarity [PDF]

Cellular and Molecular Life Sciences, 2016
E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial sheets. Through the homophilic association of E-Cadherin molecules expressed on neighboring cells, they ensure intercellular adhesion amongst epithelial cells, and regulate many key aspects of epithelial biology.
Peter Coopman, Alexandre Djiane
exaly   +4 more sources

Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells. [PDF]

PLoS ONE, 2012
Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations.We used cultures of freshly
Christof Keller, Sven Kroening, Jonathan Zuehlke, Frank Kunath, Bettina Krueger, Margarete Goppelt-Struebe   +5 more
doaj   +5 more sources

Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis

Frontiers in Cellular and Infection Microbiology
Epithelial barriers serve as critical defense lines against microbial infiltration and maintain tissue homeostasis. E-cadherin, an essential component of adherens junctions, has emerged as a pivotal molecule that secures epithelial homeostasis.
Peter Lialios, Peter Lialios, Stella Alimperti, Stella Alimperti   +3 more
doaj   +3 more sources

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]

, 2010
Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C. Walker, Jennifer Southgate, Kurt Anderson, Lisa A. Kirkwood, Nikolaos T. Georgopoulos   +4 more
core   +12 more sources

Cadherin Expression and EMT: A Focus on Gliomas

Biomedicines, 2021
Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination.
Carolina Noronha, Ana Sofia Ribeiro, Ricardo Taipa, Diogo S. Castro, Joaquim Reis, Cláudia Faria, Joana Paredes   +6 more
doaj   +1 more source

A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. [PDF]

PLoS ONE, 2015
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells.
Svetlana N Rubtsova, Irina Y Zhitnyak, Natalya A Gloushankova   +2 more
doaj   +1 more source

P-Cadherin Regulates Intestinal Epithelial Cell Migration and Mucosal Repair, but Is Dispensable for Colitis Associated Colon Cancer

Cells, 2022
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer ...
Nayden G. Naydenov, Susana Lechuga, Ajay Zalavadia, Pranab K. Mukherjee, Ilyssa O. Gordon, David Skvasik, Petra Vidovic, Emina Huang, Florian Rieder, Andrei I. Ivanov   +9 more
doaj   +1 more source

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function

Frontiers in Immunology, 2023
Neutrophil extracellular traps contribute to lung injury in cystic fibrosis and asthma, but the mechanisms are poorly understood. We sought to understand the impact of human NETs on barrier function in primary human bronchial epithelial and a human ...
K. M. Hudock, K. M. Hudock, K. M. Hudock, M. S. Collins, M. A. Imbrogno, E. L. Kramer, E. L. Kramer, J. J. Brewington, J. J. Brewington, A. Ziady, A. Ziady, N. Zhang, N. Zhang, J. Snowball, Y. Xu, Y. Xu, Y. Xu, B. C. Carey, B. C. Carey, Y. Horio, Y. Horio, S. M. O’Grady, S. M. O’Grady, E. J. Kopras, J. Meeker, H. Morgan, A. J. Ostmann, E. Skala, M. E. Siefert, C. L. Na, C. R. Davidson, K. Gollomp, K. Gollomp, N. Mangalmurti, N. Mangalmurti, B. C. Trapnell, B. C. Trapnell, B. C. Trapnell, J. P. Clancy   +38 more
doaj   +1 more source

Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. [PDF]

PLoS ONE, 2016
BACKGROUND:Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype.
Elizabeth J Sandquist, Seema Somji, Jane R Dunlevy, Scott H Garrett, Xu Dong Zhou, Andrea Slusser-Nore, Donald A Sens   +6 more
doaj   +1 more source

Induction of the epithelial-mesenchymal transition in the endometrium by chronic endometritis in infertile patients.

PLoS ONE, 2021
BackgroundThe purpose of the present study was to evaluate the relationship between chronic endometritis and the epithelial-mesenchymal transition in the endometrium of infertile patients in the implantation phase.MethodsEndometrial biopsy specimens from
Mitsuaki Ishida, Akie Takebayashi, Fuminori Kimura, Akiko Nakamura, Jun Kitazawa, Aina Morimune, Tetsuro Hanada, Koji Tsuta, Takashi Murakami   +8 more
doaj   +1 more source