Results 1 to 10 of about 127,702 (262)

SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium. [PDF]

PLoS ONE, 2014
Expression of the cellular adhesion protein N-cadherin is a critical event during epithelial-mesenchymal transition (EMT). The SMAD4 protein has been identified as a mediator of transforming growth factor-β (TGF-β) superfamily signaling, which regulates ...
Ya'an Kang, Jianhua Ling, Rei Suzuki, David Roife, Xavier Chopin-Laly, Mark J Truty, Deyali Chatterjee, Huamin Wang, Ryan M Thomas, Matthew H Katz, Paul J Chiao, Jason B Fleming   +11 more
doaj   +1 more source

Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine

Toxins, 2019
Clostridium perfringens strains B and C cause fatal intestinal diseases in animals. The secreted pore-forming toxin delta-toxin is one of the virulence factors of the strains, but the mechanism of intestinal pathogenesis is unclear. Here, we investigated
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama   +3 more
doaj   +1 more source

WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. [PDF]

PLoS ONE, 2013
Epithelial morphogenesis is a dynamic process that involves coordination of signaling and actin cytoskeletal rearrangements.We analyzed the contribution of the branched actin regulator WAVE2 in the development of 3-dimensional (3D) epithelial structures.
Nicole S Bryce, Albert B Reynolds, Anthony J Koleske, Alissa M Weaver   +3 more
doaj   +1 more source

Immunohistochemical expression of E-cadherin and N-cadherin in endometrioid endometrial carcinoma and its precursor lesions

Clinical Epidemiology and Global Health, 2023
Objectives: Endometrial carcinoma (EC), majority being endometroid endometrial carcinoma (EEC), is the most common invasive gynecological cancer world-wide.
Sunita Yadav, Annu Makkar, Preeti Agarwal, Uma Singh, Uma Shankar Singh, Madhu Mati Goel   +5 more
doaj   +1 more source

Epithelial-mesenchymal interconversions in ovarian cancer: the levels and functions of E-cadherin in intraabdominal dissemination

Oncology Reviews, 2020
The metastatic process of ovarian cancer (OC) is almost exclusively defined by direct shedding of tumor cells into the abdominal cavity, followed by clustering into multicellular aggregates and posterior peritoneal anchorage.
Ricardo J. Roque, Margarida Figueiredo Dias, Filipa Costa Sousa   +2 more
doaj   +1 more source

E-cadherin loss in RMG-1 cells inhibits cell migration and its regulation by Rho GTPases

Biochemistry and Biophysics Reports, 2019
E-cadherin is an adherens junction protein that forms intercellular contacts in epithelial cells. Downregulation of E-cadherin is frequently observed in epithelial tumors and it is a hallmark of epithelial–mesenchymal transition (EMT).
Misako Haraguchi, Tomoko Fukushige, Takuro Kanekura, Masayuki Ozawa   +3 more
doaj   +1 more source

YES‐associated protein‐regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps

Immunity, Inflammation and Disease, 2023
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) was potentially due to the epithelial barrier injury. YES‐associated protein (YAP) is a multifunctional transcriptional factor and plays versatile roles in the regulation and maintenance of ...
Xiaocong Jiang, Longlan Shu, Yijun Liu, Yang Shen, Xia Ke, Jie Liu, Yucheng Yang   +6 more
doaj   +1 more source

E-cadherin expression in the tongue epithelium of streptozotocin-induced diabetic rats: an exploratory study

Acta Odontologica Scandinavica
Objective: Little was found on the association between diabetes and its effect on epithelial intercellular adhesion. However, no study reported the association between hyperglycemia and E-cadherin-mediated cell adhesion in tongue epithelium.
Hassan Hamed Kaabi, Abdullah Mohamed Alsoghier, Islam Abdulrahim Alredah, Rayan Mohammed Alqahtani, Ibrahim Suliman Alsanie, Hanan Abdulgafour Balto   +5 more
doaj   +1 more source

The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells.

PLoS ONE, 2016
The mitochondrial Bcl-2 inhibitor of transcription 1 (Bit1) protein is part of an anoikis-regulating pathway that is selectively dependent on integrins.
Xin Yao, Tri Pham, Brandi Temple, Selena Gray, Cornita Cannon, Renwei Chen, Asim B Abdel-Mageed, Hector Biliran   +7 more
doaj   +1 more source

Chlamydia trachomatis Infection Is Associated with E-Cadherin Promoter Methylation, Downregulation of E-Cadherin Expression, and Increased Expression of Fibronectin and α-SMA—Implications for Epithelial-Mesenchymal Transition

Frontiers in Cellular and Infection Microbiology, 2017
Chlamydia trachomatis (Ct) can induce scarring disease of the ocular mucosa, known as trachoma, the most common infectious cause of blindness worldwide.
Jovana Rajić, Aleksandra Inic-Kanada, Elisabeth Stein, Svetlana Dinić, Nadine Schuerer, Aleksandra Uskoković, Ehsan Ghasemian, Mirjana Mihailović, Melita Vidaković, Nevena Grdović, Talin Barisani-Asenbauer   +10 more
doaj   +1 more source