Results 21 to 30 of about 131,334 (259)

P-Cadherin Regulates Intestinal Epithelial Cell Migration and Mucosal Repair, but Is Dispensable for Colitis Associated Colon Cancer

Cells, 2022
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer ...
Nayden G. Naydenov, Susana Lechuga, Ajay Zalavadia, Pranab K. Mukherjee, Ilyssa O. Gordon, David Skvasik, Petra Vidovic, Emina Huang, Florian Rieder, Andrei I. Ivanov   +9 more
doaj   +1 more source

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function

Frontiers in Immunology, 2023
Neutrophil extracellular traps contribute to lung injury in cystic fibrosis and asthma, but the mechanisms are poorly understood. We sought to understand the impact of human NETs on barrier function in primary human bronchial epithelial and a human ...
K. M. Hudock, K. M. Hudock, K. M. Hudock, M. S. Collins, M. A. Imbrogno, E. L. Kramer, E. L. Kramer, J. J. Brewington, J. J. Brewington, A. Ziady, A. Ziady, N. Zhang, N. Zhang, J. Snowball, Y. Xu, Y. Xu, Y. Xu, B. C. Carey, B. C. Carey, Y. Horio, Y. Horio, S. M. O’Grady, S. M. O’Grady, E. J. Kopras, J. Meeker, H. Morgan, A. J. Ostmann, E. Skala, M. E. Siefert, C. L. Na, C. R. Davidson, K. Gollomp, K. Gollomp, N. Mangalmurti, N. Mangalmurti, B. C. Trapnell, B. C. Trapnell, B. C. Trapnell, J. P. Clancy   +38 more
doaj   +1 more source

Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. [PDF]

PLoS ONE, 2016
BACKGROUND:Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype.
Elizabeth J Sandquist, Seema Somji, Jane R Dunlevy, Scott H Garrett, Xu Dong Zhou, Andrea Slusser-Nore, Donald A Sens   +6 more
doaj   +1 more source

Induction of the epithelial-mesenchymal transition in the endometrium by chronic endometritis in infertile patients.

PLoS ONE, 2021
BackgroundThe purpose of the present study was to evaluate the relationship between chronic endometritis and the epithelial-mesenchymal transition in the endometrium of infertile patients in the implantation phase.MethodsEndometrial biopsy specimens from
Mitsuaki Ishida, Akie Takebayashi, Fuminori Kimura, Akiko Nakamura, Jun Kitazawa, Aina Morimune, Tetsuro Hanada, Koji Tsuta, Takashi Murakami   +8 more
doaj   +1 more source

Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. [PDF]

PLoS ONE, 2010
Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin expression (known as cadherin switching) are a common mechanism for ...
Laura J Lewis-Tuffin, Fausto Rodriguez, Caterina Giannini, Bernd Scheithauer, Brian M Necela, Jann N Sarkaria, Panos Z Anastasiadis   +6 more
doaj   +1 more source

Induction of entosis by epithelial cadherin expression [PDF]

Cell Research, 2014
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as ...
Qiang, Sun, Edmund S, Cibas, Hongyan, Huang, Louis, Hodgson, Michael, Overholtzer   +4 more
openaire   +2 more sources

Role of E-Cadherin in Epithelial Architecture Maintenance [PDF]

Cell Communication & Adhesion, 2010
Morphogenesis and architecture of a developing epithelium is controlled by both cell shape and contacts, mediated by spatially and temporally regulated cell adhesion molecules. The authors study if E-cadherin functions as a key factor of epithelial adhesion and epidermal architecture in vivo.
Izaguirre, María Fernanda, Larrea, D., Adur, Javier Fernando, Diaz Zamboni, Javier Eduardo, Vicente, N. B., Galetto, Carolina, Casco, Victor Hugo   +6 more
openaire   +3 more sources

E-cadherin on epithelial–mesenchymal transition in thyroid cancer [PDF]

Cancer Cell International, 2021
AbstractThyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets.
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng   +3 more
openaire   +3 more sources

Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo. [PDF]

PLoS ONE, 2018
The retinal pigment epithelium (RPE) supports the health and function of retinal photoreceptors and is essential for normal vision. RPE cells are post-mitotic, terminally differentiated, and polarized epithelial cells. In pathological conditions, however,
Xue Yang, Jin-Yong Chung, Usha Rai, Noriko Esumi   +3 more
doaj   +1 more source

Vangl2 Regulates E-Cadherin in Epithelial Cells [PDF]

Scientific Reports, 2014
E-cadherin belongs to the classic cadherin subfamily of calcium-dependent cell adhesion molecules and is crucial for the formation and function of epithelial adherens junctions. In this study, we demonstrate that Vangl2, a vertebrate regulator of planar cell polarity (PCP), controls E-cadherin in epithelial cells.
Nagaoka, Tadahiro, Inutsuka, Ayumu, Begum, Khadiza, hafiz, Khandakar musabbir bin, Kishi, Masashi   +4 more
openaire   +2 more sources