E-cadherin on epithelial–mesenchymal transition in thyroid cancer [PDF]
Cancer Cell International, 2021 AbstractThyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets.
Xiaoyu Zhu +3 more
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Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. [PDF]
PLoS ONE, 2010 Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin expression (known as cadherin switching) are a common mechanism for ...
Laura J Lewis-Tuffin +6 more
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Role of E-Cadherin in Epithelial Architecture Maintenance [PDF]
Cell Communication & Adhesion, 2010 Morphogenesis and architecture of a developing epithelium is controlled by both cell shape and contacts, mediated by spatially and temporally regulated cell adhesion molecules. The authors study if E-cadherin functions as a key factor of epithelial adhesion and epidermal architecture in vivo.
Izaguirre, María Fernanda +6 more
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Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo. [PDF]
PLoS ONE, 2018 The retinal pigment epithelium (RPE) supports the health and function of retinal photoreceptors and is essential for normal vision. RPE cells are post-mitotic, terminally differentiated, and polarized epithelial cells. In pathological conditions, however,
Xue Yang +3 more
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Vangl2 Regulates E-Cadherin in Epithelial Cells [PDF]
Scientific Reports, 2014 E-cadherin belongs to the classic cadherin subfamily of calcium-dependent cell adhesion molecules and is crucial for the formation and function of epithelial adherens junctions. In this study, we demonstrate that Vangl2, a vertebrate regulator of planar cell polarity (PCP), controls E-cadherin in epithelial cells.
Nagaoka, Tadahiro +4 more
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Cadherin-23 mediates heterotypic cell-cell adhesion between breast cancer epithelial cells and fibroblasts. [PDF]
PLoS ONE, 2012 In the early stages of breast cancer metastasis, epithelial cells penetrate the basement membrane and invade the surrounding stroma, where they encounter fibroblasts.
Maria Apostolopoulou, Lee Ligon
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CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion. [PDF]
PLoS ONE, 2011 E-cadherin is frequently lost during epithelial-mesenchymal transition and the progression of epithelial tumorigenesis. We found a marker of epithelial-mesenchymal transition, CD44, upregulated in response to functional loss of E-cadherin in esophageal ...
Grégoire F Le Bras +5 more
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Cadherin and Integrin Regulation of Epithelial Cell Migration [PDF]
Langmuir, 2009 These studies quantified the relative effects of E-cadherin expression and homophilic ligation on the integrin-mediated motility of epithelial cells. Micropatterned proteins were used to quantitatively titrate the ligation of E-cadherin and integrin receptors in order to assess their coordinate influence on the migration velocities of MDA-MB-231 breast
Jonathan, Silvestre +2 more
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Soluble E‐cadherin: A marker of genital epithelial disruption
American Journal of Reproductive Immunology, 2022 AbstractProblemThe genital epithelial barrier is a crucial first line of defence against HIV, and epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial integrity requires biopsies, but their collection is not practical in many research settings.
Rachel Liu +10 more
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Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]
PLoS ONE, 2016 Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly +4 more
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