Results 131 to 140 of about 182,825 (308)

A study of the predictive value of morphometric assessments in clinical outcome in ovarian epithelial malignancy [PDF]

Quantitative pathology as a tool in gynaecological pathology is fairly new. Such techniques allow greater objectivity than histological grading, typing, and residual tumour estimation.
Palmer, Julia Elizabeth
core  

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

The Characteristics of Sociodemography, Histopathologic Features, Stage, and Management of Ovarian Cancer in Dr. Ramelan Navy Hospital Surabaya

Indonesian Journal of Cancer
Background: Ovarian cancer is considered a silent killer disease, mainly due to the late diagnosis. It is often diagnosed at an advanced stage, thus increasing the mortality rate.
Karina Rahmalia , Ketut Edy Sudiarta, Herin Setianingsih, Wienta Diarsvitri   +3 more
doaj   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

The inflammatory infiltrate of high-grade serous carcinoma omental metastasis [PDF]

, 2014
PhDThe aim of this thesis is to investigate the role of inflammatory infiltrates and chemokines in metastasis of high-grade serous ovarian cancer, HGSC, to the omentum using human tissue biopsies and a 3- dimensional (3D) cell culture model.
Everitt, Gemma Louise Ann
core  

The PAX8 cistrome in epithelial ovarian cancer

, 2017
PAX8 is a lineage-restricted transcription factor that is expressed in epithelial ovarian cancer (EOC) precursor tissues, and in the major EOC histotypes.
Gayther, Simon A., Sowter, H, Sowter, Heidi M., Dennis J. Hazelett, Lee, J, Hazelett, Dennis J., Lawrenson, K, Rodriguez-Malave, N, Mhawech-Fauceglia, P, Rosario I. Corona, Corona, R, Adler, Emily K., Janet M. Lee, Kate Lawrenson, Simon A. Gayther, Paulette Mhawech-Fauceglia, Hazelett, D, Mhawech-Fauceglia, Paulette, Emily K. Adler, Lee, Janet M., Norma Rodriguez-Malave, Heidi Sowter, Adler, E, Gayther, S, Lawrenson, Kate, Rodriguez-Malave, Norma, Corona, Rosario I.   +26 more
core   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Attenuated Salmonella typhimurium L forms suppress tumor growth and promote apoptosis in murine ovarian tumors

Scientific Reports
To study the effects of attenuated Salmonella typhimurium L forms on the in vivo tumorigenicity and apoptosis of murine epithelial ovarian cancer cells, as well as the related mechanisms.
Yunjie Zhang, Ziqing Tang, Yidan Shao, Xiaoli Yue, Yifan Chu, Dengyu Chen   +5 more
doaj   +1 more source

Clinically Informed Intelligent Classification of Ovarian Cancer Cells by Label‐Free Holographic Imaging Flow Cytometry

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quantitative phase maps of single cells recorded in flow cytometry modality feed a hierarchical architecture of machine learning models for the label‐free identification of subtypes of ovarian cancer. The employment of a priori clinical information improves the classification performance, thus emulating the clinical application of liquid biopsy during ...
Daniele Pirone, Beatrice Cavina, Daniele Gaetano Sirico, Martina Mugnano, Vittorio Bianco, Lisa Miccio, Anna Myriam Perrone, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac, Pasquale Memmolo, Pietro Ferraro   +11 more
wiley   +1 more source