Results 91 to 100 of about 87,269,478 (305)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Universality of a mesenchymal transition signature in invasive solid cancers [PDF]

, 2012
In this brief communication, additional computational validation is provided consistent with the unifying hypothesis that a shared biological mechanism of mesenchymal transition, reflected by a precise gene expression signature, may be present in all ...
Dimitris Anastassiou
core  

Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices

, 2014
In proteinuric nephropathy, epithelial-to-mesenchymal transition (EMT) is an important mechanism that causes renal interstitial fibrosis. The precise role of EMT in the pathogenesis of fibrosis remains controversial, partly due to the absence of suitable
Qin, Jianhua, Lin, Hongli, Zhou, Mengying, Hongli Lin, Ma, Huipeng, 秦建华   +5 more
core   +1 more source

Epithelial-mesenchymal transition derived cells exhibit multi lineage differentiation potential similar to mesenchymal stem cells [PDF]

, 2010
The epithelial-to-mesenchymal transition (EMT) is an embryonic process that becomes latent in most normal adult tissues. Recently, we have shown that induction of EMT endows breast epithelial cells with stem cell traits.
Brett George Hollier, Guerra, R, Evans, KW, Brisken, Cathrin, Mani, Sendurai A., Hollier, Brett G., Shi, Yuexi, Battula, VL, Michael Andreeff, Andreeff, Michael, Ayyanan, A, Rudy Guerra, Cathrin Brisken, Brisken, C, Shi, Y, Marini, FC, Rui-yu Wang, Marini, Frank C., Andreeff, M, Battula, Venkata Lokesh, Kurt Evans, Brett G. Hollier, Yuexi Shi, Wang, RY, Guerra, Rudy, Sendurai A. Mani, Hollier, Brett George, Ayyanan, Ayyakkannu, Frank C. Marini, Mani, SA, Ayyakkannu Ayyanan, Evans, Kurt William, Kurt William Evans, Wang, Rui-Yu, Venkata Lokesh Battula   +34 more
core   +1 more source

The mechanisms of colorectal cancer cell mesenchymal–epithelial transition induced by hepatocyte exosome-derived miR-203a-3p

Journal of Bio-X Research, 2018
. Phosphatase of regenerating liver 3 (PRL3) promotes colorectal cancer (CRC) metastasis by inducing epithelial-to-mesenchymal transition. Mesenchymal-to-epithelial transition (MET), the opposite of epithelial-to-mesenchymal transition, has been proposed
Heyang Xu, MD, Yongliang Huang, MD, Qiusheng Lan, MD, Yang Zhang, MD, Yujie Zeng, PhD, Tao Zhang, BA, Chisheng Chen, MD, Pengwei Su, BA, Ziqiang Chu, BA, Wei Lai, MD, Zhonghua Chu, MD   +10 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Loss of breast epithelial marker hCLCA2 promotes epithelial to mesenchymal transition and indicates higher risk of metastasis [PDF]

, 2011
Transition between epithelial and mesenchymal states is a feature of both normal development and tumor progression. We report that expression of chloride channel accessory protein hCLCA2 is a characteristic of epithelial differentiation in the ...
S A Mani, Yu, Y., Rao, K., R C Elble, Elble, R., Walia, V., J Cheng, Hollier, B.G., Y Yu, B G Hollier, J R McLean, Sun, M., M Sun, Cao, D., McLean, J.R., Mani, S.A., D Cao, Premkumar, L., V Walia, L Premkumar, K Rao, Cheng, J.   +21 more
core   +1 more source

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

Stem Cell Reports, 2014
Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, and contribute to relapse.
Suling Liu, Yang Cong, Dong Wang, Yu Sun, Lu Deng, Yajing Liu, Rachel Martin-Trevino, Li Shang, Sean P. McDermott, Melissa D. Landis, Suhyung Hong, April Adams, Rosemarie D’Angelo, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Shawn G. Clouthier, Daniel Birnbaum, Stephen T. Wong, Ming Zhan, Jenny C. Chang, Max S. Wicha   +20 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells. [PDF]

, 2011
Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis.
Friedman, N, Oliver Eickelberg, Yu, H, Richards, T., Kaplan, Tommy, Yingze Zhang, Kaplan, T, Pandit, Kusum V., Zhang, Y., Kusum V. Pandit, Richards, Thomas, Benos, Panayiotis V., Zeng, Q, Bais, A.S., Pandit, K.V., Kaminski, N., Handley, D, Bais, Abha S, Richards, T, Panayiotis V. Benos, Handley, Daniel, Richards Thomas, Haiying Yu, Bais, AS, Eickelberg, O, Benos, PV, Nir Friedman, Handley, D., Tommy Kaplan, Friedman, N., Pandit, Kusum V, Zeng, Q., Zhang, Yingze, Abha S Bais, Eickelberg, O., Kusum V Pandit, Bais Abha S., Zeng, Qilu, Yu, Haiying, Panayiotis V Benos, Kaplan, T., Eickelberg Oliver, Kaminski, N, Benos, Panayiotis V, Benos, P.V., Thomas Richards, Eickelberg, Oliver, Naftali Kaminski, Zeng Qilu, Daniel Handley, Pandit, KV, Bais, Abha S., Zhang, Y, Yu Haiying, Kaminski, Naftali, Yu, H., Qilu Zeng, Kaminski Naftali, Benos Panayiotis V., Handley Daniel, Friedman, Nir, Pandit Kusum V., Zhang Yingze, Kaplan Tommy, Friedman Nir, Abha S. Bais   +65 more
core   +1 more source