Results 191 to 200 of about 87,269,478 (305)

Emerging roles of ATR beyond DNA damage repair: orchestrating transcriptional reprogramming during epithelial-to-mesenchymal transition. [PDF]

J Clin Invest
Mestre-Farrera A, Hu Z, Yang J.
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression. [PDF]

J Clin Invest
Tu X, Zeng X, Sun Y, Ouyang Y, Zhu L, Yin P, Pavelko K, Leon-Ferre R, Jiang Y, Dong H, Carter J, Zhu S, Sarkaria JN, Wang L, Huang J, Luo K, Han Y, Wu Z, Lou Z, Mutter RW.   +19 more
europepmc   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Intrinsic cellular heterogeneity directs divergent epithelial-to-mesenchymal transition outcomes. [PDF]

FEBS J
Ozkuru Sekeroglu E, Yıldız ŞN, Yetkin S, Kafaz GI, Sengez B, Erez O, Ersöz Gülseven E, Cakan-Akdogan G, Batur T, Alotaibi H.   +9 more
europepmc   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis. [PDF]

Oncogene
Sadeqi Nezhad M, Harris CR, Prela O, Narrow W, Breitenbach M, Wang L, Jain S, Becker JL, Bagci B, Hao Y, Hezel AF, Gerber SA, Mello S, Withers T, Carpizo DR.   +14 more
europepmc   +1 more source

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Advanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi   +15 more
wiley   +1 more source

CXCL14 promotes osteosarcoma cell migration and invasion by inducing epithelial-to-mesenchymal transition. [PDF]

Int J Med Sci
Hou CH, Hsu ML, Wang CH, Liu JF, Chen PC.   +4 more
europepmc   +1 more source