Results 61 to 70 of about 207,813 (264)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives

Cancer Management and Research, 2014
Antonio Díaz-López,1 Gema Moreno-Bueno,1,2 Amparo Cano11Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM ...
Díaz-López A, Moreno-Bueno G, Cano A   +2 more
doaj  

MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney tubules, renal vesicles, comma- and s-shaped bodies in human kidney

European Journal of Histochemistry, 2012
MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features.
V. Fanos, G. Faa, S. Mellou, G. Monga, P. Van Eyken, S. Nemolato, C. Gerosa, A. Locci, N. Iacovidou, D. Fanni   +9 more
doaj   +2 more sources

IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma

Translational Neuroscience, 2021
In cancer, kappa B-interacting protein (IKBIP) has rarely been reported. This study aimed at investigating its expression pattern and biological function in brain glioma at the transcriptional level.
Yang Ying, Wang Jin, Xu Shihai, Lv Wen, Shi Fei, Shan Aijun   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evidence for mesenchymal-epithelial transition associated with mouse hepatic stem cell differentiation.

PLoS ONE, 2011
UnlabelledMesenchymal-epithelial transition events are related to embryonic development, tissue construction, and wound healing. Stem cells are involved in all of these processes, at least in part.
Bin Li, Yun-Wen Zheng, Yuuki Sano, Hideki Taniguchi   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma

The Scientific World Journal, 2010
Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer ...
Carla Cano, Yoshiharu Motoo, Juan L. Iovanna   +2 more
doaj   +1 more source

The mechanisms of colorectal cancer cell mesenchymal–epithelial transition induced by hepatocyte exosome-derived miR-203a-3p

Journal of Bio-X Research, 2018
. Phosphatase of regenerating liver 3 (PRL3) promotes colorectal cancer (CRC) metastasis by inducing epithelial-to-mesenchymal transition. Mesenchymal-to-epithelial transition (MET), the opposite of epithelial-to-mesenchymal transition, has been proposed
Heyang Xu, MD, Yongliang Huang, MD, Qiusheng Lan, MD, Yang Zhang, MD, Yujie Zeng, PhD, Tao Zhang, BA, Chisheng Chen, MD, Pengwei Su, BA, Ziqiang Chu, BA, Wei Lai, MD, Zhonghua Chu, MD   +10 more
doaj   +1 more source