Results 91 to 100 of about 1,205,235 (393)

Ca²⁺ Signaling by TRPV4 Channels in Respiratory Function and Disease

Cells, 2021
Members of the transient receptor potential (TRP) superfamily are broadly expressed in our body and contribute to multiple cellular functions. Most interestingly, the fourth member of the vanilloid family of TRP channels (TRPV4) serves different ...
Suhasini Rajan, Christian Schremmer, Jonas Weber, Philipp Alt, Fabienne Geiger, Alexander Dietrich   +5 more
doaj   +1 more source

Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]

, 2012
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine, Iber, Dagmar, Menshykau, Denis   +2 more
core   +3 more sources

Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]

, 2020
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J, Chen, Yuzhang, Darmanis, Spyros, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Le, Daniel D, Li, Ke-Xin, Neff, Norma, Padovano, Valeria, Sinclair, Adriane W, Sit, Rene, Tan, Michelle, Wu, Bing, Ye, Wenlei   +14 more
core   +1 more source

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

Journal of Experimental Medicine, 2017
A variant of the autophagy gene ATG16L1 is associated with Crohn’s disease, an inflammatory bowel disease (IBD), and poor survival in allogeneic hematopoietic stem cell transplant recipients.
Yu Matsuzawa-Ishimoto, Y. Shono, L. E. Gómez, Vanessa M Hubbard-Lucey, M. Cammer, J. Neil, M. Dewan, Sophia R Lieberman, A. Lazrak, Jill M. Marinis, A. Beal, P. Harris, J. Bertin, Chen Liu, Yi Ding, M. Brink, M. Brink, K. Cadwell   +17 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Regulation of interleukin 33/ST2 signaling of human corneal epithelium in allergic diseases

International Journal of Ophthalmology, 2013
AIM: To identify the function of ST2 and explore the role of IL-33/ST2 signaling in regulating the pro-allergic cytokine production in human corneal epithelial cells (HCECs).METHODS: Human corneal tissues and cultured primary HCECs were treated with IL ...
Jing Lin
doaj   +1 more source

Modeling Notch-Induced Tumor Cell Survival in the Drosophila Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation

Cells, 2021
Notch is a conserved developmental signaling pathway that is dysregulated in many cancer types, most often through constitutive activation. Tumor cells with nuclear accumulation of the active Notch receptor, NICD, generally exhibit enhanced survival ...
Allison Jevitt, Yi-Chun Huang, Su-Mei Zhang, Deeptiman Chatterjee, Xian-Feng Wang, Geng-Qiang Xie, Wu-Min Deng   +6 more
doaj   +1 more source

Bioaccumulation of PCB & DDE methyl sulfones in marine mammals and their interactions with receptor proteins [PDF]

, 2000
PCB and DDE-Methyl sulphone metabolites are the product of enzymatic and bile acid entero hepatic metabolism in the final phase (III) of PCB and DDE detoxification in mammals following hepatic microsomal cytochrome P450-dependent metabolism (phase I) and
Aguilar, A, Borrell, A, Haraguchi, K, Mattson, M, Siebert, U, Troisi, GM   +5 more
core  

THE EPITHELIUM OF THE BUCCAL MUCOSA [PDF]

British Journal of Dermatology, 1908
n ...
openaire   +2 more sources

Apoptosis and the Airway Epithelium [PDF]

Journal of Allergy, 2011
The airway epithelium functions as a barrier and front line of host defense in the lung. Apoptosis or programmed cell death can be elicited in the epithelium as a response to viral infection, exposure to allergen or to environmental toxins, or to drugs.
openaire   +3 more sources