Results 21 to 30 of about 1,223,923 (392)

Vectorial Release of Human RNA Viruses from Epithelial Cells

Viruses, 2022
Epithelial cells are apico-basolateral polarized cells that line all tubular organs and are often targets for infectious agents. This review focuses on the release of human RNA virus particles from both sides of polarized human cells grown on transwells.
Sabine Chapuy-Regaud, Claire Allioux, Nicolas Capelli, Marion Migueres, Sébastien Lhomme, Jacques Izopet   +5 more
doaj   +1 more source

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes

Gut Microbes, 2022
Psychological stress alters the gut microbiota and predisposes individuals to increased risk for enteric infections and chronic bowel conditions. Intestinal epithelial cells (IECs) are responsible for maintaining homeostatic interactions between the gut ...
Jacob M. Allen, Amy R. Mackos, Robert M. Jaggers, Patricia C. Brewster, Mikaela Webb, Chia-Hao Lin, Chris Ladaika, Ronald Davies, Peter White, Brett R. Loman, Michael T. Bailey   +10 more
doaj   +1 more source

A Tissue-Engineered Tracheobronchial In Vitro Co-Culture Model for Determining Epithelial Toxicological and Inflammatory Responses

Biomedicines, 2021
Translation of novel inhalable therapies for respiratory diseases is hampered due to the lack of in vitro cell models that reflect the complexity of native tissue, resulting in many novel drugs and formulations failing to progress beyond preclinical ...
Luis Soriano, Tehreem Khalid, Fergal J. O’Brien, Cian O’Leary, Sally-Ann Cryan   +4 more
doaj   +1 more source

Modeling Notch-Induced Tumor Cell Survival in the Drosophila Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation

Cells, 2021
Notch is a conserved developmental signaling pathway that is dysregulated in many cancer types, most often through constitutive activation. Tumor cells with nuclear accumulation of the active Notch receptor, NICD, generally exhibit enhanced survival ...
Allison Jevitt, Yi-Chun Huang, Su-Mei Zhang, Deeptiman Chatterjee, Xian-Feng Wang, Geng-Qiang Xie, Wu-Min Deng   +6 more
doaj   +1 more source

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Proceedings of the National Academy of Sciences of the United States of America, 2013
Obesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes ...
A. Everard, C. Belzer, L. Geurts, J. P. Ouwerkerk, Céline Druart, L. Bindels, Y. Guiot, M. Derrien, G. Muccioli, N. Delzenne, W. D. de Vos, Patrice D Cani   +11 more
semanticscholar   +1 more source

Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells [PDF]

, 2019
The gingival epithelium is a physical and immunological barrier to the microbiota of the oral cavity, which interact through soluble mediators with the immune cells that patrol the tissue at the gingival epithelium.
Bradshaw, David, Brown, Jason L., Butcher, John, Culshaw, Shauna, Delaney, Chris, Johnston, William, Khan, Shaz, Rajendran, Ranjith, Ramage, Gordon   +8 more
core   +4 more sources

Immunomodulation of Epithelium [PDF]

Canadian Journal of Gastroenterology, 1994
Many studies have provided evidence that the immune system is a key regulatory system of intestinal function. The interaction of immune cells with the gut epithelium plays an important role in host defence, acting to eliminate pathogens, antigens and other noxious material from the lumen of the gastrointestinal tract.
openaire   +2 more sources

Expression profiling of ascorbic acid–related transporters in human and mouse eyes [PDF]

, 2016
PURPOSE: Ascorbic acid (AsA) is an important antioxidant in the eye. Ascorbic acid is usually transported by sodium-dependent AsA transporters (SVCTs), and dehydroascorbic acid (DHA) by glucose transporters (GLUTs).
Beebe, David, Dana, Belinda, Huang, Andrew, Huang, Jie, Kubota, Miyuki, Liu, Margaret, Liu, Ying, Ma, Nan, Shui, Ying-Bo, Siegfried, Carla, Yan, Hong   +10 more
core   +2 more sources

Intestinal fatty acid binding protein regulates mitochondrion β-oxidation and cholesterol uptake

Journal of Lipid Research, 2008
The role of intestinal fatty acid binding protein (I-FABP) in lipid metabolism remains elusive. To address this issue, normal human intestinal epithelial cells (HIEC-6) were transfected with cDNA to overexpress I-FABP and compared with cells treated with
Alain Montoudis, Ernest Seidman, François Boudreau, Jean-François Beaulieu, Daniel Menard, Mounib Elchebly, Geneviève Mailhot, Alain-Theophile Sane, Marie Lambert, Edgard Delvin, Emile Levy   +10 more
doaj   +1 more source

Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis

Frontiers in Cell and Developmental Biology, 2020
Dilation of bronchi and bronchioles caused by destruction and excessive epithelial remodeling is a characteristic feature of bronchiectasis. It is not known how epithelial progenitor cells contribute to these pathologic conditions in peripheral airways ...
Yang Peng, Yang Peng, Ai-ru Xu, Shi-ying Chen, Yan Huang, Xiao-rong Han, Wei-jie Guan, De-Yun Wang, Nan-shan Zhong   +8 more
doaj   +1 more source